Exploiting biocatalysis in the synthesis of supramolecular polymers

Sangita Roy, Rein V. Ulijn

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

10 Citations (Scopus)

Abstract

This chapter details the exploitation of biocatalysis in generating supramolecular polymers. This approach provides highly dynamic supramolecular structures, inspired by biological polymeric systems found in the intra- and extracellular space. The molecular design of the self-assembling precursors is discussed in terms of enzyme recognition, molecular switching mechanisms and non-covalent interactions that drive the supramolecular polymerisation process, with an emphasis on aromatic peptide amphiphiles. We discuss a number of unique features of these systems, including spatiotemporal control of nucleation and growth of supramolecular polymers and the possibility of kinetically controlling mechanical properties. Fully reversible systems that operate under thermodynamic control allow for defect correction and selection of the most stable structures from mixtures of monomers. Finally, a number of potential applications of enzymatic supramolecular polymerisations are discussed in the context of biomedicine and nanotechnology.

LanguageEnglish
Title of host publicationEnzymatic polymerisation
EditorsAnja R. A. Palmans, Andreas Heise
Place of PublicationBerlin
Pages127-143
Number of pages17
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Polymer Science
PublisherSpringer
Volume237
ISSN (Print)0065-3195

Fingerprint

Polymers
Polymerization
Molecular recognition
Amphiphiles
Nanotechnology
Nucleation
Monomers
Thermodynamics
Mechanical properties
Defects
Peptides
Enzymes
Biocatalysis

Keywords

  • synthesis of supramolecular polymers
  • biocatalysis
  • supramolecular polymers
  • enzymes
  • peptides
  • molecular hydrogel Self-assembly

Cite this

Roy, S., & Ulijn, R. V. (2010). Exploiting biocatalysis in the synthesis of supramolecular polymers. In A. R. A. Palmans, & A. Heise (Eds.), Enzymatic polymerisation (pp. 127-143). (Advances in Polymer Science; Vol. 237). Berlin. https://doi.org/10.1007/12_2010_75
Roy, Sangita ; Ulijn, Rein V. / Exploiting biocatalysis in the synthesis of supramolecular polymers. Enzymatic polymerisation. editor / Anja R. A. Palmans ; Andreas Heise. Berlin, 2010. pp. 127-143 (Advances in Polymer Science).
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Roy, S & Ulijn, RV 2010, Exploiting biocatalysis in the synthesis of supramolecular polymers. in ARA Palmans & A Heise (eds), Enzymatic polymerisation. Advances in Polymer Science, vol. 237, Berlin, pp. 127-143. https://doi.org/10.1007/12_2010_75

Exploiting biocatalysis in the synthesis of supramolecular polymers. / Roy, Sangita; Ulijn, Rein V.

Enzymatic polymerisation. ed. / Anja R. A. Palmans; Andreas Heise. Berlin, 2010. p. 127-143 (Advances in Polymer Science; Vol. 237).

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

TY - CHAP

T1 - Exploiting biocatalysis in the synthesis of supramolecular polymers

AU - Roy, Sangita

AU - Ulijn, Rein V.

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N2 - This chapter details the exploitation of biocatalysis in generating supramolecular polymers. This approach provides highly dynamic supramolecular structures, inspired by biological polymeric systems found in the intra- and extracellular space. The molecular design of the self-assembling precursors is discussed in terms of enzyme recognition, molecular switching mechanisms and non-covalent interactions that drive the supramolecular polymerisation process, with an emphasis on aromatic peptide amphiphiles. We discuss a number of unique features of these systems, including spatiotemporal control of nucleation and growth of supramolecular polymers and the possibility of kinetically controlling mechanical properties. Fully reversible systems that operate under thermodynamic control allow for defect correction and selection of the most stable structures from mixtures of monomers. Finally, a number of potential applications of enzymatic supramolecular polymerisations are discussed in the context of biomedicine and nanotechnology.

AB - This chapter details the exploitation of biocatalysis in generating supramolecular polymers. This approach provides highly dynamic supramolecular structures, inspired by biological polymeric systems found in the intra- and extracellular space. The molecular design of the self-assembling precursors is discussed in terms of enzyme recognition, molecular switching mechanisms and non-covalent interactions that drive the supramolecular polymerisation process, with an emphasis on aromatic peptide amphiphiles. We discuss a number of unique features of these systems, including spatiotemporal control of nucleation and growth of supramolecular polymers and the possibility of kinetically controlling mechanical properties. Fully reversible systems that operate under thermodynamic control allow for defect correction and selection of the most stable structures from mixtures of monomers. Finally, a number of potential applications of enzymatic supramolecular polymerisations are discussed in the context of biomedicine and nanotechnology.

KW - synthesis of supramolecular polymers

KW - biocatalysis

KW - supramolecular polymers

KW - enzymes

KW - peptides

KW - molecular hydrogel Self-assembly

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DO - 10.1007/12_2010_75

M3 - Other chapter contribution

SN - 9783642163753

T3 - Advances in Polymer Science

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BT - Enzymatic polymerisation

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Roy S, Ulijn RV. Exploiting biocatalysis in the synthesis of supramolecular polymers. In Palmans ARA, Heise A, editors, Enzymatic polymerisation. Berlin. 2010. p. 127-143. (Advances in Polymer Science). https://doi.org/10.1007/12_2010_75