Experimental studies of pedunculopontine functions: are they motor, sensory or integrative?

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The pedunculopontine tegmental nucleus (PPTg) is involved in Parkinson's disease and has become a therapeutic target. However, its normal functions are uncertain: are they motor, sensory or integrative? This position paper reviews PPTg structure and considers experiments designed to understand its behavioural functions. The PPTg is part of the corticostriatal architecture and, consistent with this, a core deficit following lesion is the inability to properly establish action-outcome associations. Understanding normal PPTg structure and function will provide insight into the role it has in Parkinson's disease and related disorders, and will benefit the development of surgical treatments aimed here.
LanguageEnglish
PagesS194-8
Number of pages5
JournalParkinsonism and Related Disorders
Volume14 Suppl 2
DOIs
Publication statusPublished - 2008

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Pedunculopontine Tegmental Nucleus
Parkinson Disease
Therapeutics

Keywords

  • animals
  • deep brain stimulation
  • neural pathways
  • parkinson disease
  • pedunculopontine tegmental nucleus

Cite this

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abstract = "The pedunculopontine tegmental nucleus (PPTg) is involved in Parkinson's disease and has become a therapeutic target. However, its normal functions are uncertain: are they motor, sensory or integrative? This position paper reviews PPTg structure and considers experiments designed to understand its behavioural functions. The PPTg is part of the corticostriatal architecture and, consistent with this, a core deficit following lesion is the inability to properly establish action-outcome associations. Understanding normal PPTg structure and function will provide insight into the role it has in Parkinson's disease and related disorders, and will benefit the development of surgical treatments aimed here.",
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Experimental studies of pedunculopontine functions: are they motor, sensory or integrative? / Winn, Philip.

In: Parkinsonism and Related Disorders , Vol. 14 Suppl 2, 2008, p. S194-8.

Research output: Contribution to journalArticle

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