Expanding, integrating, sensing and responding: the role of Primary metabolism in specialised metabolite production

Lorena T. Fernandez-Martinez, Paul A. Hoskisson

Research output: Contribution to journalArticle

Abstract

Producing specialised metabolites such as antibiotics, immunosuppressives, anti-cancer agents and anti-helminthics draws on primary metabolism to provide the building blocks for biosynthesis. The growth phase-dependent nature of production means that producing organisms must deal with the metabolic conflicts of declining growth rate, reduced nutrient availability, specialised metabolite production and potentially morphological development. In recent years, our understanding of gene expansion events, integration of metabolic function and gene regulation events that facilitate the sensing and responding to metabolite concentrations has grown, but new data are constantly expanding our horizons. This review highlights the role evolutionary gene or pathway expansion plays in primary metabolism and examine the adoption of enzymes for specialised metabolism. We also look at recent insights into sensing and responding to metabolites.

LanguageEnglish
Pages16-21
Number of pages6
JournalCurrent Opinion in Microbiology
Volume51
Early online date18 Apr 2019
DOIs
Publication statusPublished - 1 Oct 2019

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Genes
Immunosuppressive Agents
Growth
Anti-Bacterial Agents
Food
Enzymes
Neoplasms

Keywords

  • antibiotics
  • immunosuppressives
  • biosynthesis

Cite this

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Expanding, integrating, sensing and responding : the role of Primary metabolism in specialised metabolite production. / Fernandez-Martinez, Lorena T.; Hoskisson, Paul A.

In: Current Opinion in Microbiology, Vol. 51, 01.10.2019, p. 16-21.

Research output: Contribution to journalArticle

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