Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

Jens Atzrodt, Volker Derdau, William J. Kerr, Marc Reid, Patrick Rojahn, Remo Weck

Research output: Contribution to journalArticle

40 Citations (Scopus)
67 Downloads (Pure)

Abstract

An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series
Original languageEnglish
Pages (from-to)1924-1929
Number of pages6
JournalTetrahedron
Volume71
Issue number13
Early online date12 Feb 2015
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • hydrogen isotope exchange
  • deuterium labelling
  • iridium catalysis
  • N-Heterocyclic carbene
  • heterocycles

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