Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

Jens Atzrodt, Volker Derdau, William J. Kerr, Marc Reid, Patrick Rojahn, Remo Weck

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series
LanguageEnglish
Pages1924-1929
Number of pages6
JournalTetrahedron
Volume71
Issue number13
Early online date12 Feb 2015
DOIs
Publication statusPublished - 1 Apr 2015

Fingerprint

phosphine
Drug Labeling
Isotopes
Hydrogen
Catalysts
Labeling
Chemical activation
Molecules
Substrates
Pharmaceutical Preparations
Experiments

Keywords

  • hydrogen isotope exchange
  • deuterium labelling
  • iridium catalysis
  • N-Heterocyclic carbene
  • heterocycles

Cite this

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abstract = "An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments, and labelling of drug type molecules have revealed PR3 = PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series",
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Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles. / Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc; Rojahn, Patrick; Weck, Remo.

In: Tetrahedron, Vol. 71, No. 13, 01.04.2015, p. 1924-1929.

Research output: Contribution to journalArticle

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AU - Rojahn, Patrick

AU - Weck, Remo

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KW - deuterium labelling

KW - iridium catalysis

KW - N-Heterocyclic carbene

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