Exosomes: fighting cancer with cancer

Hanin Alyamani; Mohammad A Obeid; Rothwelle J Tate; Valerie A Ferro

doi:10.4155/tde-2018-0051

Exosomes: fighting cancer with cancer

Hanin Alyamani, Mohammad A Obeid, Rothwelle J Tate, Valerie A Ferro

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.

Original language	English
Journal	Therapeutic Delivery
Volume	10
Issue number	1
Early online date	7 Dec 2018
DOIs	https://doi.org/10.4155/tde-2018-0051
Publication status	E-pub ahead of print - 7 Dec 2018

Keywords

angiogenesis
cancer
diagnostic
exosomes
immune system
immunosuppression
miRNA
nucleic acid
progression
therapeutic

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10.4155/tde-2018-0051

Alyamani-etal-TD-2018-Exosomes-fighting-cancer-with-cancerAccepted author manuscript, 1.07 MB

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title = "Exosomes: fighting cancer with cancer",

abstract = "Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.",

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AU - Obeid, Mohammad A

AU - Tate, Rothwelle J

AU - Ferro, Valerie A

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AB - Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.

KW - angiogenesis

KW - cancer

KW - diagnostic

KW - exosomes

KW - immune system

KW - immunosuppression

KW - miRNA

KW - nucleic acid

KW - progression

KW - therapeutic

UR - https://www.future-science.com/journal/tde

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M3 - Review article

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Exosomes: fighting cancer with cancer

Abstract

Keywords

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