Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Janice M Phillips, Mary P Latimer, Sonali Gupta, Philip Winn, Verity J Brown

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Abstract

We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalBehavioural Brain Research
Volume90
Issue number1
DOIs
Publication statusPublished - 31 Jan 1998

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Keywords

  • basal ganglia
  • Parkinson's disease
  • rat
  • sensorimotor asymmetry
  • subthalamic nucleus

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