Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Janice M Phillips; Mary P Latimer; Sonali Gupta; Philip Winn; Verity J Brown

doi:10.1016/S0166-4328(97)00080-6

Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Janice M Phillips, Mary P Latimer, Sonali Gupta, Philip Winn, Verity J Brown

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	Behavioural Brain Research
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/S0166-4328(97)00080-6
Publication status	Published - 31 Jan 1998

Funding

This work was supported by The Wellcome Trust, Project Grant no. 040551/Z/94. We gratefully acknowledge the expert assistance of the technical staff of the Animal House of the School of Psychology.

Keywords

basal ganglia
Parkinson's disease
rat
sensorimotor asymmetry
subthalamic nucleus

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AU - Latimer, Mary P

AU - Gupta, Sonali

AU - Winn, Philip

AU - Brown, Verity J

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AB - We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

KW - basal ganglia

KW - Parkinson's disease

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Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Abstract

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