Excitotoxic lesions of the pedunculopontine tegmental nucleus in rats impair performance on a test of sustained attention

Rouba Kozak, Eric M. Bowman, Mary P. Latimer, Claire L. Rostron, Philip Winn

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Recent research has suggested that the pontomesencephalic tegmentum might be an important part of a network underlying sustained attention. The largest structure of the pontomesencephalic tegmentum is the pedunculopontine tegmental nucleus, which has ascending connections to thalamus and with corticostriatal systems. In this experiment we examined the performance of rats following bilateral excitotoxic lesions of the pedunculopontine tegmental nucleus on a test of sustained attention previously used to examine frontal cortical function. After an initial period of darkness, the rats had to attend continuously to a dim stimulus light that would, at unpredictable intervals, become transiently brighter. During this period of increased stimulus brightness the rats could press a lever to obtain a food reward. Rats were trained to a criterion level of performance before lesions were made. After surgery, sham lesioned rats (n=7) resumed accurate responding, with an average successful detection rate of ∼70%. Pedunculopontine lesioned rats (n=7), however, only achieved a successful detection rate of ∼40%. When the duration of the bright target stimulus was increased from 1.5 to 4 s, the performance of the pedunculopontine lesioned rats significantly improved. The observation that an increase in brightness duration caused a marked improvement in lesioned rats' performance suggests strongly that the impairment was in attention rather than motor ability or simple sensory processing. These data are taken to be consistent with the hypothesis that the pedunculopontine tegmental nucleus is an important part of a network maintaining attention.

LanguageEnglish
Pages257-264
Number of pages8
JournalExperimental Brain Research
Volume162
Issue number2
Early online date19 Nov 2004
DOIs
Publication statusPublished - 30 Apr 2005

Fingerprint

Pedunculopontine Tegmental Nucleus
Aptitude
Darkness
Thalamus
Reward
Light
Food

Keywords

  • acetylcholine
  • ascending reticular activating system
  • basal forebrain
  • corticostriatal
  • executive function
  • pontomesencephalic tegmentum
  • thalamus

Cite this

Kozak, Rouba ; Bowman, Eric M. ; Latimer, Mary P. ; Rostron, Claire L. ; Winn, Philip. / Excitotoxic lesions of the pedunculopontine tegmental nucleus in rats impair performance on a test of sustained attention. In: Experimental Brain Research. 2005 ; Vol. 162, No. 2. pp. 257-264.
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Excitotoxic lesions of the pedunculopontine tegmental nucleus in rats impair performance on a test of sustained attention. / Kozak, Rouba; Bowman, Eric M.; Latimer, Mary P.; Rostron, Claire L.; Winn, Philip.

In: Experimental Brain Research, Vol. 162, No. 2, 30.04.2005, p. 257-264.

Research output: Contribution to journalArticle

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