Excitatory microcircuits within superficial layers of the medial entorhinal cortex

Jochen Winterer, Nikolaus Maier, Christian Wozny, Prateep Beed, Jörg Breustedt, Roberta Evangelista, Yangfan Peng, Tiziano D'Albis, Richard Kempter, Dietmar Schmitz

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Abstract

The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depends on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid-cell patterns.
Original languageEnglish
Pages (from-to)1110-1116
Number of pages7
JournalCell Reports
Volume19
Issue number6
DOIs
Publication statusPublished - 9 May 2017

Keywords

  • cell connectivity
  • cell grid patterns
  • medial entorhinal cortex

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    Winterer, J., Maier, N., Wozny, C., Beed, P., Breustedt, J., Evangelista, R., Peng, Y., D'Albis, T., Kempter, R., & Schmitz, D. (2017). Excitatory microcircuits within superficial layers of the medial entorhinal cortex. Cell Reports, 19(6), 1110-1116. https://doi.org/10.1016/j.celrep.2017.04.041