Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A Parkinson; Fraser J Scott; Colin J Suckling; Gail Wilson

doi:10.1039/C3MD00071K

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A Parkinson, Fraser J Scott, Colin J Suckling, Gail Wilson

Pure And Applied Chemistry

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9 Citations (Scopus)

123 Downloads (Pure)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Original language	English
Pages (from-to)	1105-1108
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	7
Early online date	20 May 2013
DOIs	https://doi.org/10.1039/C3MD00071K
Publication status	Published - 2013

Keywords

antibacterial DNA
DNA oligomers

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10.1039/C3MD00071K

C3md00071kFinal published version, 348 KB

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title = "Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences",

abstract = "An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.",

keywords = "antibacterial DNA, DNA oligomers",

author = "Parkinson, {John A} and Scott, {Fraser J} and Suckling, {Colin J} and Gail Wilson",

year = "2013",

doi = "10.1039/C3MD00071K",

language = "English",

volume = "4",

pages = "1105--1108",

journal = "MedChemComm",

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T1 - Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

AU - Parkinson, John A

AU - Scott, Fraser J

AU - Suckling, Colin J

AU - Wilson, Gail

PY - 2013

Y1 - 2013

N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

KW - antibacterial DNA

KW - DNA oligomers

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U2 - 10.1039/C3MD00071K

DO - 10.1039/C3MD00071K

M3 - Article

VL - 4

SP - 1105

EP - 1108

JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Abstract

Keywords

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