Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

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Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.
Original languageEnglish
Pages (from-to)1105-1108
Number of pages4
JournalMedChemComm
Volume4
Issue number7
Early online date20 May 2013
DOIs
Publication statusPublished - 2013

Keywords

  • antibacterial DNA
  • DNA oligomers

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