Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A Parkinson, Fraser J Scott, Colin J Suckling, Gail Wilson

Research output: Contribution to journal › Article

7 Citations (Scopus)
91 Downloads (Pure)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.
Original languageEnglish
Pages (from-to)1105-1108
Number of pages4
JournalMedChemComm
Volume4
Issue number7
Early online date20 May 2013
DOIs
Publication statusPublished - 2013

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Binders
DNA
Oligomers
Temperature
Therapeutics
Experiments

Keywords

  • antibacterial DNA
  • DNA oligomers

Cite this

Parkinson, John A ; Scott, Fraser J ; Suckling, Colin J ; Wilson, Gail. / Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences. In: MedChemComm. 2013 ; Vol. 4, No. 7. pp. 1105-1108.
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Parkinson, JA, Scott, FJ, Suckling, CJ & Wilson, G 2013, 'Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences', MedChemComm, vol. 4, no. 7, pp. 1105-1108. https://doi.org/10.1039/C3MD00071K

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences. / Parkinson, John A; Scott, Fraser J; Suckling, Colin J; Wilson, Gail.

In: MedChemComm, Vol. 4, No. 7, 2013, p. 1105-1108.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

AU - Parkinson, John A

AU - Scott, Fraser J

AU - Suckling, Colin J

AU - Wilson, Gail

PY - 2013

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N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

KW - antibacterial DNA

KW - DNA oligomers

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U2 - 10.1039/C3MD00071K

DO - 10.1039/C3MD00071K

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Parkinson JA, Scott FJ, Suckling CJ, Wilson G. Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences. MedChemComm. 2013;4(7):1105-1108. https://doi.org/10.1039/C3MD00071K

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