Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.
LanguageEnglish
Pages1105-1108
Number of pages4
JournalMedChemComm
Volume4
Issue number7
Early online date20 May 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Binders
DNA
Oligomers
Temperature
Therapeutics
Experiments

Keywords

  • antibacterial DNA
  • DNA oligomers

Cite this

@article{8d2269f14382483fbf3ca4c6767ff9ff,
title = "Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences",
abstract = "An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.",
keywords = "antibacterial DNA, DNA oligomers",
author = "Parkinson, {John A} and Scott, {Fraser J} and Suckling, {Colin J} and Gail Wilson",
year = "2013",
doi = "10.1039/C3MD00071K",
language = "English",
volume = "4",
pages = "1105--1108",
journal = "MedChemComm",
issn = "2040-2503",
number = "7",

}

TY - JOUR

T1 - Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

AU - Parkinson, John A

AU - Scott, Fraser J

AU - Suckling, Colin J

AU - Wilson, Gail

PY - 2013

Y1 - 2013

N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

KW - antibacterial DNA

KW - DNA oligomers

UR - http://www.scopus.com/inward/record.url?scp=84879848223&partnerID=8YFLogxK

U2 - 10.1039/C3MD00071K

DO - 10.1039/C3MD00071K

M3 - Article

VL - 4

SP - 1105

EP - 1108

JO - MedChemComm

T2 - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 7

ER -