Exact model reduction of combinatorial reaction networks

Holger Conzelmann, Dirk Fey, Ernst D Gilles

Research output: Contribution to journalArticle

41 Citations (Scopus)
14 Downloads (Pure)

Abstract

Receptors and scaffold proteins usually possess a high number of distinct binding domains inducing the formation of large multiprotein signaling complexes. Due to combinatorial reasons the number of distinguishable species grows exponentially with the number of binding domains and can easily reach several millions. Even by including only a limited number of components and binding domains the resulting models are very large and hardly manageable. A novel model reduction technique allows the significant reduction and modularization of these models.
Original languageEnglish
Article number78
Number of pages25
JournalBMC Systems Biology
Volume2
DOIs
Publication statusPublished - 28 Aug 2008

Keywords

  • combinatorial reaction networks
  • receptors
  • scaffold proteins
  • multi-scaffold complexes
  • binding domains

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