@article{4a6174164dc149c6a2dc24a47e762701,
title = "Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease.",
abstract = "A four step process of high quality modelling of existing data, deconstruction, identification of replacement cores and an innovative synthetic re-growth strategy led to the rapid discovery of a novel oral series of PI3K δ inhibitors with promising selectivity and excellent in vivo characteristics.",
keywords = "PI3Kδ inhibitors, respiratory disease, bioavailability, deconstruction, hinge-binding groups, optimisation, indazole core, physicochemical properties, pharmacokinetic properties",
author = "Augustin Amour and Nick Barton and Cooper, {Anthony W.J.} and Graham Inglis and Craig Jamieson and Luscombe, {Christopher N.} and David Perez and Simon Peace and Paul Rowland and Chris Tame and Sorif Uddin and Giovanni Vitulli and Natalie Wellaway",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://dx.doi.org10.1021/acs.jmedchem.6b00799",
year = "2016",
month = jul,
day = "18",
doi = "10.1021/acs.jmedchem.6b00799",
language = "English",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
}
