Evolution, epidemiology and diversity of Corynebacterium diphtheriae: new perspectives on an old foe

Vartul Sangal, Paul A. Hoskisson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Diphtheria is a debilitating disease caused by toxigenic Corynebacterium diphtheriae strains and has been effectively controlled by the toxoid vaccine, yet several recent outbreaks have been reported across the globe. Moreover, non-toxigenic C. diphtheriae strains are emerging as a major global health concern by causing severe pharyngitis and tonsillitis, endocarditis, septic arthritis and osteomyelitis. Molecular epidemiological investigations suggest the existence of outbreak-associated clones with multiple genotypes circulating around the world. Evolution and pathogenesis appears to be driven by recombination as major virulence factors, including the tox gene and pilus gene clusters, are found within genomic islands that appear to be mobile between strains. The number of pilus gene clusters and variation introduced by gain or loss of gene function correlate with the variable adhesive and invasive properties of C. diphtheriae strains. Genomic variation does not support the separation of C. diphtheriae strains into biovars which correlates well with findings of studies based on multilocus sequence typing. Genomic analyses of a relatively small number of strains also revealed a recombination driven diversification of strains within a sequence type and indicate a wider diversity among C. diphtheriae strains than previously appreciated. This suggests that there is a need for increased effort from the scientific community to study C. diphtheriae to help understand the genomic diversity and pathogenicity within the population of this important human pathogen.
LanguageEnglish
Pages364-370
Number of pages7
JournalInfection, Genetics and Evolution
Volume43
Early online date9 Jun 2016
DOIs
Publication statusPublished - 30 Sep 2016

Fingerprint

Corynebacterium diphtheriae
epidemiology
genomics
Epidemiology
gene
recombination
Multigene Family
Genetic Recombination
Disease Outbreaks
fimbriae
vaccine
pathogenicity
virulence
multigene family
Toxoids
Genomic Islands
Multilocus Sequence Typing
clone
Tonsillitis
Infectious Arthritis

Keywords

  • Corynebacterium diphtheriae
  • diphtheria
  • biovar
  • evolution
  • MLST

Cite this

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abstract = "Diphtheria is a debilitating disease caused by toxigenic Corynebacterium diphtheriae strains and has been effectively controlled by the toxoid vaccine, yet several recent outbreaks have been reported across the globe. Moreover, non-toxigenic C. diphtheriae strains are emerging as a major global health concern by causing severe pharyngitis and tonsillitis, endocarditis, septic arthritis and osteomyelitis. Molecular epidemiological investigations suggest the existence of outbreak-associated clones with multiple genotypes circulating around the world. Evolution and pathogenesis appears to be driven by recombination as major virulence factors, including the tox gene and pilus gene clusters, are found within genomic islands that appear to be mobile between strains. The number of pilus gene clusters and variation introduced by gain or loss of gene function correlate with the variable adhesive and invasive properties of C. diphtheriae strains. Genomic variation does not support the separation of C. diphtheriae strains into biovars which correlates well with findings of studies based on multilocus sequence typing. Genomic analyses of a relatively small number of strains also revealed a recombination driven diversification of strains within a sequence type and indicate a wider diversity among C. diphtheriae strains than previously appreciated. This suggests that there is a need for increased effort from the scientific community to study C. diphtheriae to help understand the genomic diversity and pathogenicity within the population of this important human pathogen.",
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Evolution, epidemiology and diversity of Corynebacterium diphtheriae : new perspectives on an old foe. / Sangal, Vartul; Hoskisson, Paul A.

In: Infection, Genetics and Evolution, Vol. 43, 30.09.2016, p. 364-370.

Research output: Contribution to journalArticle

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