Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry

Nuria Fontanals Torroja, Núria Miralles, Norhayati Abdullah, Arlene Davies, Núria Gilart, Peter A.G. Cormack

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This paper presents eight distinct strong cation-exchange resins, all of which were derived from precursor resins that had been synthesised using either precipitation polymerisation or non-aqueous dispersion polymerisation. The precursor resins were transformed into the corresponding strong cation-exchange resins by hypercrosslinking followed by polymer analogous reactions, to yield materials with high specific surface areas and strong cation-exchange character.

These novel resins were then evaluated as strong cation-exchange (SCX) sorbents in the solid-phase extraction (SPE) of a group of drugs from aqueous samples. Following preliminary experiments, the two best-performing resins were then evaluated in solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE/LC-MS/MS) to determine a group of drugs from sewage samples. In general, use of these sorbents led to excellent recovery values (75% - 100%) for most of the target drugs and negligible matrix effects (ME) (< 20% ion suppression/enhancement of the analyte signal), when 50 mL and 25 mL of effluent and influent sewage water samples, respectively, were percolated through the resins. Finally, a validated method based on SPE/LC-MS/MS was used to quantify the target drugs present in different sewage samples
Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Chromatography A
Volume1343
Early online date4 Apr 2014
DOIs
Publication statusPublished - 23 May 2014

Keywords

  • strong cation-exchange
  • solid-phase extraction
  • recovery
  • matrix effect
  • sewage

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