Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry

Nuria Fontanals Torroja, Núria Miralles, Norhayati Abdullah, Arlene Davies, Núria Gilart, Peter A.G. Cormack

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This paper presents eight distinct strong cation-exchange resins, all of which were derived from precursor resins that had been synthesised using either precipitation polymerisation or non-aqueous dispersion polymerisation. The precursor resins were transformed into the corresponding strong cation-exchange resins by hypercrosslinking followed by polymer analogous reactions, to yield materials with high specific surface areas and strong cation-exchange character.

These novel resins were then evaluated as strong cation-exchange (SCX) sorbents in the solid-phase extraction (SPE) of a group of drugs from aqueous samples. Following preliminary experiments, the two best-performing resins were then evaluated in solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE/LC-MS/MS) to determine a group of drugs from sewage samples. In general, use of these sorbents led to excellent recovery values (75% - 100%) for most of the target drugs and negligible matrix effects (ME) (< 20% ion suppression/enhancement of the analyte signal), when 50 mL and 25 mL of effluent and influent sewage water samples, respectively, were percolated through the resins. Finally, a validated method based on SPE/LC-MS/MS was used to quantify the target drugs present in different sewage samples
LanguageEnglish
Pages55-62
Number of pages8
JournalJournal of Chromatography A
Volume1343
Early online date4 Apr 2014
DOIs
Publication statusPublished - 23 May 2014

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Solid Phase Extraction
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Cations
Polymers
Resins
Sewage
Cation Exchange Resins
Polymerization
Pharmaceutical Preparations
Sorbents
Specific surface area
Ions
Effluents
Ion exchange
Water
Recovery
Experiments

Keywords

  • strong cation-exchange
  • solid-phase extraction
  • recovery
  • matrix effect
  • sewage

Cite this

Fontanals Torroja, Nuria ; Miralles, Núria ; Abdullah, Norhayati ; Davies, Arlene ; Gilart, Núria ; Cormack, Peter A.G. / Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry. In: Journal of Chromatography A . 2014 ; Vol. 1343. pp. 55-62.
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Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry. / Fontanals Torroja, Nuria; Miralles, Núria; Abdullah, Norhayati; Davies, Arlene; Gilart, Núria; Cormack, Peter A.G.

In: Journal of Chromatography A , Vol. 1343, 23.05.2014, p. 55-62.

Research output: Contribution to journalArticle

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