TY - JOUR
T1 - Evaluation of quality of life outcomes following palliative radiotherapy in bone metastases
T2 - a literature review
AU - Koufopoulou, Christina
AU - Mosa, Eftychia
AU - Charalampakis, Nick
AU - Nikolaou, Michail
AU - Tsoukalas, Nikolaos
AU - Nixon, Ioanna
AU - Saraireh, Haytham
AU - Hajiioannou, Jiannis
AU - Kardamakis, Dimitrios
AU - Kyrgias, George
AU - Tolia, Maria
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Purpose: To assess the quality of life (QoL) following palliative radiotherapy (RT) in patients with painful bone metastases. Methods: A literature search limited to English-written publications was carried out, through the Cochrane Central Register of Controlled Trials (November 2018), OvidSP and PubMedCentral (1940-November 2018) databases. Subject headings and keywords included "quality of life"(QoL), "bone metastases", "palliative therapy", "pain" and "radiotherapy". Original articles, literature reviews, trials and meta-analyses revealing alterations in QoL post-RT using ratified measuring tools were examined. Studies referring to other types of metastases (e.g. brain metastases), or to other types of palliative therapy (e.g. the use of bisphosphonates alone), or focusing only on pain, or even reporting QoL only before or only after the use of RT were excluded. Results: Twenty four articles were selected from a total of 1360 articles. Seven trials proceeded to patients' randomization. The most commonly used tool to evaluate QoL was EORTC, followed by Brief Pain Inventory (BPI) and Edmonton Symptom Assessment System (ESAS) questionnaires. All studies showed improvement in symptoms and functional interference scores after RT. The QoL between responders (Rs) and non-responders (NRs) has been juxtaposed in 10 studies. Rs had a significant benefit in QoL in comparison with the NRs. Discussion: Palliative radiotherapy in painful bone metastases improves Rs' QoL.
AB - Purpose: To assess the quality of life (QoL) following palliative radiotherapy (RT) in patients with painful bone metastases. Methods: A literature search limited to English-written publications was carried out, through the Cochrane Central Register of Controlled Trials (November 2018), OvidSP and PubMedCentral (1940-November 2018) databases. Subject headings and keywords included "quality of life"(QoL), "bone metastases", "palliative therapy", "pain" and "radiotherapy". Original articles, literature reviews, trials and meta-analyses revealing alterations in QoL post-RT using ratified measuring tools were examined. Studies referring to other types of metastases (e.g. brain metastases), or to other types of palliative therapy (e.g. the use of bisphosphonates alone), or focusing only on pain, or even reporting QoL only before or only after the use of RT were excluded. Results: Twenty four articles were selected from a total of 1360 articles. Seven trials proceeded to patients' randomization. The most commonly used tool to evaluate QoL was EORTC, followed by Brief Pain Inventory (BPI) and Edmonton Symptom Assessment System (ESAS) questionnaires. All studies showed improvement in symptoms and functional interference scores after RT. The QoL between responders (Rs) and non-responders (NRs) has been juxtaposed in 10 studies. Rs had a significant benefit in QoL in comparison with the NRs. Discussion: Palliative radiotherapy in painful bone metastases improves Rs' QoL.
KW - quality of life
KW - bone metastases
KW - palliative therapy
KW - pain
KW - radiotherapy
UR - https://www.jbuon.com/archive/24-5-1747.pdf
UR - https://jbuon.com/
M3 - Article
SN - 2241-6293
VL - 24
SP - 1747
EP - 1760
JO - Journal of B.U.ON.: official journal of the Balkan Union of Oncology
JF - Journal of B.U.ON.: official journal of the Balkan Union of Oncology
ER -