Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Lerato Hlaka, Michael-Jon Rosslee, Mumin Ozturk, Santosh Kumar, Suraj Parihar, Frank Brombacher, Abedawn Khalaf, Katharine Carter, Fraser Scott, Colin Suckling, Reto Guler

Research output: Contribution to journalArticle

5 Citations (Scopus)
16 Downloads (Pure)

Abstract

The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.
Original languageEnglish
Pages (from-to)3334–3341
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume72
Issue number12
Early online date18 Sep 2017
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • drug discovery
  • minor groove binder
  • tuberculosis

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