Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Lerato Hlaka, Michael-Jon Rosslee, Mumin Ozturk, Santosh Kumar, Suraj Parihar, Frank Brombacher, Abedawn Khalaf, Katharine Carter, Fraser Scott, Colin Suckling, Reto Guler

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.
LanguageEnglish
Pages3334–3341
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume72
Issue number12
Early online date18 Sep 2017
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Nonionic surfactants
Mycobacterium tuberculosis
Surface-Active Agents
Binders
Anti-Bacterial Agents
Drug therapy
Mycobacterium Infections
Drug Discovery
Pharmaceutical Preparations
Tuberculosis
Drug Therapy
Therapeutics

Keywords

  • drug discovery
  • minor groove binder
  • tuberculosis

Cite this

Hlaka, Lerato ; Rosslee, Michael-Jon ; Ozturk, Mumin ; Kumar, Santosh ; Parihar, Suraj ; Brombacher, Frank ; Khalaf, Abedawn ; Carter, Katharine ; Scott, Fraser ; Suckling, Colin ; Guler, Reto. / Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. In: Journal of Antimicrobial Chemotherapy. 2017 ; Vol. 72, No. 12. pp. 3334–3341.
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Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. / Hlaka, Lerato; Rosslee, Michael-Jon; Ozturk, Mumin; Kumar, Santosh; Parihar, Suraj; Brombacher, Frank; Khalaf, Abedawn; Carter, Katharine; Scott, Fraser; Suckling, Colin; Guler, Reto.

In: Journal of Antimicrobial Chemotherapy, Vol. 72, No. 12, 01.12.2017, p. 3334–3341.

Research output: Contribution to journalArticle

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