Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Lerato Hlaka; Michael-Jon Rosslee; Mumin Ozturk; Santosh Kumar; Suraj Parihar; Frank Brombacher; Abedawn Khalaf; Katharine Carter; Fraser Scott; Colin Suckling; Reto Guler

doi:10.1093/jac/dkx326

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Lerato Hlaka, Michael-Jon Rosslee, Mumin Ozturk, Santosh Kumar, Suraj Parihar, Frank Brombacher, Abedawn Khalaf, Katharine Carter, Fraser Scott, Colin Suckling, Reto Guler

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

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Abstract

The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.

Original language	English
Pages (from-to)	3334–3341
Number of pages	8
Journal	Journal of Antimicrobial Chemotherapy
Volume	72
Issue number	12
Early online date	18 Sep 2017
DOIs	https://doi.org/10.1093/jac/dkx326
Publication status	Published - 1 Dec 2017

Keywords

drug discovery
minor groove binder
tuberculosis

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10.1093/jac/dkx326

Hlaka-etal-JAC-2017-Evaluation-of-Minor-Groove-Binders-MGBs-as-novel-anti-mycobacterial-agentsAccepted author manuscript, 1.12 MB

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Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C., & Guler, R. (2017). Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. Journal of Antimicrobial Chemotherapy, 72(12), 3334–3341. https://doi.org/10.1093/jac/dkx326

Hlaka, Lerato ; Rosslee, Michael-Jon ; Ozturk, Mumin ; Kumar, Santosh ; Parihar, Suraj ; Brombacher, Frank ; Khalaf, Abedawn ; Carter, Katharine ; Scott, Fraser ; Suckling, Colin ; Guler, Reto. / Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. In: Journal of Antimicrobial Chemotherapy. 2017 ; Vol. 72, No. 12. pp. 3334–3341.

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abstract = "The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb. ",

keywords = "drug discovery, minor groove binder, tuberculosis",

author = "Lerato Hlaka and Michael-Jon Rosslee and Mumin Ozturk and Santosh Kumar and Suraj Parihar and Frank Brombacher and Abedawn Khalaf and Katharine Carter and Fraser Scott and Colin Suckling and Reto Guler",

note = "This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The version of record Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., ... Guler, R. (2017). Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. Journal of Antimicrobial Chemotherapy, 72(12), 3334–3341, is available online at: https://doi.org/10.1093/jac/dkx326. ",

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Hlaka, L, Rosslee, M-J, Ozturk, M, Kumar, S, Parihar, S, Brombacher, F, Khalaf, A, Carter, K , Scott, F , Suckling, C & Guler, R 2017, 'Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy', Journal of Antimicrobial Chemotherapy, vol. 72, no. 12, pp. 3334–3341. https://doi.org/10.1093/jac/dkx326

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. / Hlaka, Lerato; Rosslee, Michael-Jon; Ozturk, Mumin; Kumar, Santosh; Parihar, Suraj; Brombacher, Frank; Khalaf, Abedawn; Carter, Katharine ; Scott, Fraser ; Suckling, Colin; Guler, Reto.

In: Journal of Antimicrobial Chemotherapy, Vol. 72, No. 12, 01.12.2017, p. 3334–3341.

Research output: Contribution to journal › Article › peer-review

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T1 - Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

AU - Hlaka, Lerato

AU - Rosslee, Michael-Jon

AU - Ozturk, Mumin

AU - Kumar, Santosh

AU - Parihar, Suraj

AU - Brombacher, Frank

AU - Khalaf, Abedawn

AU - Carter, Katharine

AU - Scott, Fraser

AU - Suckling, Colin

AU - Guler, Reto

N1 - This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The version of record Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., ... Guler, R. (2017). Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. Journal of Antimicrobial Chemotherapy, 72(12), 3334–3341, is available online at: https://doi.org/10.1093/jac/dkx326.

PY - 2017/12/1

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N2 - The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.

AB - The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.

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KW - minor groove binder

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 12

ER -

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

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Katharine Carter

Fraser Scott

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Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

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Katharine Carter

Fraser Scott

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