Evaluation of antihypertensive adherence and its determinants at primary health care facilities in rural South Africa

Enos M Rampamba, Johanna C Meyer, Brian Godman, Amanj Kurdi, Elvera Helberg

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
8 Downloads (Pure)


Introduction and aim: To evaluate adherence to antihypertensive treatment in rural South Africa and identify potential determinants given concerns with adherence and its impact in this priority disease area. Method: Face-to-face interviews with hypertensive patients and rating their adherence to treatment using defined categorised responses. Associations between adherence and patient characteristics assessed and sensitivity analyses performed. Results: 54.6% of patients were adherent to treatment. Controlled blood pressure (OR = :=2.1; 95% CI [:1.1, -3.8]; p = 0.019), comorbidity (OR = :=2.0; 95% CI [: 1.1, -3.6]; p = 0.032) and smoking (OR = :=0.3; 95% CI [:0.1, -0.8]; p = 0.018) were associated with adherence. Conclusion: Adherence and BP control were suboptimal, only smoking was an independent risk factor for adherence. Adherent patients were twice as likely to have controlled BP, although results were sensitive to the definition of adherence. Initiatives are in place to improve adherence, which will be monitored.
Original languageEnglish
Pages (from-to)661-672
Number of pages12
JournalJournal of Comparative Effectiveness Research
Issue number7
Early online date11 Jun 2018
Publication statusPublished - 31 Jul 2018


  • antihypertensive treatment
  • rural South Africa
  • blood pressure

Cite this