TY - JOUR
T1 - Evaluation of a mobile phone-based, advanced symptom management system (ASyMS©) in the management of chemotherapy-related toxicity
AU - Kearney, N.
AU - McCann, L.
AU - Norrie, J.
AU - Taylor, L.
AU - Gray, P.
AU - McGee-Lennon, M.
AU - Sage, M.
AU - Miller, M.
AU - Maguire, Roma
PY - 2009/4/30
Y1 - 2009/4/30
N2 - Objectives: To evaluate the impact of a mobile phone-based, remote monitoring, advanced symptom management system (ASyMS©) on the incidence, severity and distress of six chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea) in patients with lung, breast or colorectal cancer. Design: A two group (intervention and control) by five time points (baseline, pre-cycle 2, pre-cycle 3, pre-cycle 4 and pre-cycle 5) randomised controlled trial. Setting: Seven clinical sites in the UK; five specialist cancer centres and two local district hospitals. Participants: One hundred and twelve people with breast, lung or colorectal cancer receiving outpatient chemotherapy. Interventions: A mobile phone-based, remote monitoring, advanced symptom management system (ASyMS©). Main outcome measures: Chemotherapy-related morbidity of six common chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea). Results: There were significantly higher reports of fatigue in the control group compared to the intervention group (odds ratio∈=∈2.29, 95%CI∈=∈1.04 to 5.05, P∈=∈0.040) and reports of hand-foot syndrome were on average lower in the control group (odds ratio control/intervention∈=∈0.39, 95%CI∈=∈0.17 to 0.92, P∈=∈0.031). Conclusion: The study demonstrates that ASyMS © can support the management of symptoms in patients with lung, breast and colorectal cancer receiving chemotherapy.
AB - Objectives: To evaluate the impact of a mobile phone-based, remote monitoring, advanced symptom management system (ASyMS©) on the incidence, severity and distress of six chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea) in patients with lung, breast or colorectal cancer. Design: A two group (intervention and control) by five time points (baseline, pre-cycle 2, pre-cycle 3, pre-cycle 4 and pre-cycle 5) randomised controlled trial. Setting: Seven clinical sites in the UK; five specialist cancer centres and two local district hospitals. Participants: One hundred and twelve people with breast, lung or colorectal cancer receiving outpatient chemotherapy. Interventions: A mobile phone-based, remote monitoring, advanced symptom management system (ASyMS©). Main outcome measures: Chemotherapy-related morbidity of six common chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea). Results: There were significantly higher reports of fatigue in the control group compared to the intervention group (odds ratio∈=∈2.29, 95%CI∈=∈1.04 to 5.05, P∈=∈0.040) and reports of hand-foot syndrome were on average lower in the control group (odds ratio control/intervention∈=∈0.39, 95%CI∈=∈0.17 to 0.92, P∈=∈0.031). Conclusion: The study demonstrates that ASyMS © can support the management of symptoms in patients with lung, breast and colorectal cancer receiving chemotherapy.
KW - assessment
KW - chemotherapy
KW - symptoms
KW - technology
UR - http://www.scopus.com/inward/record.url?scp=62449146918&partnerID=8YFLogxK
U2 - 10.1007/s00520-008-0515-0
DO - 10.1007/s00520-008-0515-0
M3 - Article
C2 - 18953579
AN - SCOPUS:62449146918
SN - 0941-4355
VL - 17
SP - 437
EP - 444
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 4
ER -