Evaluation of 30 insertion/deletion polymorphisms as forensic markers in the Kuwaiti population

Mahdi Haidar; Hussain Alsaleh; Penelope R. Haddrill

doi:10.1016/j.fsigss.2019.10.157

Evaluation of 30 insertion/deletion polymorphisms as forensic markers in the Kuwaiti population

Mahdi Haidar, Hussain Alsaleh, Penelope R. Haddrill

Pure And Applied Chemistry

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Abstract

Insertion/deletion (indel) polymorphism markers have been developed as a supplementary genotyping system in forensic DNA testing. The only commercial indel genotyping kit is the Qiagen Investigator® DIPplex kit, which includes 30 loci that can be typed using PCR-capillary electrophoresis (PCR-CE). We show that these 30 markers can be used to genetically assign Kuwaiti individuals to their population of origin when compared to other distant populations, using principal components analysis (PCA) and STRUCTURE. We also demonstrate a relationship between geographic and genetic distance using allele frequencies for the 30 markers from 26 populations.

Original language	English
Journal	Forensic Science International: Genetics Supplement Series
Early online date	21 Oct 2019
DOIs	https://doi.org/10.1016/j.fsigss.2019.10.157
Publication status	Published - 21 Oct 2019

Keywords

kuwait
indels
DIPplex
forensic genetics

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10.1016/j.fsigss.2019.10.157

Haidar-etal-FSI-2019-Evaluation-of-30-insertion-deletion-polymorphisms-as-forensic-markersAccepted author manuscript, 303 KBLicence: CC BY-NC-ND 4.0

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title = "Evaluation of 30 insertion/deletion polymorphisms as forensic markers in the Kuwaiti population",

abstract = "Insertion/deletion (indel) polymorphism markers have been developed as a supplementary genotyping system in forensic DNA testing. The only commercial indel genotyping kit is the Qiagen Investigator{\textregistered} DIPplex kit, which includes 30 loci that can be typed using PCR-capillary electrophoresis (PCR-CE). We show that these 30 markers can be used to genetically assign Kuwaiti individuals to their population of origin when compared to other distant populations, using principal components analysis (PCA) and STRUCTURE. We also demonstrate a relationship between geographic and genetic distance using allele frequencies for the 30 markers from 26 populations.",

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AU - Alsaleh, Hussain

AU - Haddrill, Penelope R.

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Y1 - 2019/10/21

N2 - Insertion/deletion (indel) polymorphism markers have been developed as a supplementary genotyping system in forensic DNA testing. The only commercial indel genotyping kit is the Qiagen Investigator® DIPplex kit, which includes 30 loci that can be typed using PCR-capillary electrophoresis (PCR-CE). We show that these 30 markers can be used to genetically assign Kuwaiti individuals to their population of origin when compared to other distant populations, using principal components analysis (PCA) and STRUCTURE. We also demonstrate a relationship between geographic and genetic distance using allele frequencies for the 30 markers from 26 populations.

AB - Insertion/deletion (indel) polymorphism markers have been developed as a supplementary genotyping system in forensic DNA testing. The only commercial indel genotyping kit is the Qiagen Investigator® DIPplex kit, which includes 30 loci that can be typed using PCR-capillary electrophoresis (PCR-CE). We show that these 30 markers can be used to genetically assign Kuwaiti individuals to their population of origin when compared to other distant populations, using principal components analysis (PCA) and STRUCTURE. We also demonstrate a relationship between geographic and genetic distance using allele frequencies for the 30 markers from 26 populations.

KW - kuwait

KW - indels

KW - DIPplex

KW - forensic genetics

UR - https://www.sciencedirect.com/journal/forensic-science-international-genetics-supplement-series

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DO - 10.1016/j.fsigss.2019.10.157

M3 - Article

JO - Forensic Science International: Genetics Supplement Series

JF - Forensic Science International: Genetics Supplement Series

SN - 1875-1768

ER -

Evaluation of 30 insertion/deletion polymorphisms as forensic markers in the Kuwaiti population

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Keywords

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