Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

Jens Sutter; Tereza Bidlakova; Vlastimil Fidler; Jan Karolin; David Birch

Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

Jens Sutter, Tereza Bidlakova, Vlastimil Fidler, Jan Karolin, David Birch

Research output: Contribution to conference › Poster

Abstract

Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.

Original language	English
Publication status	Published - 15 Sept 2011
Event	Nano Meets Spectroscopy (NMS) 2011 - National Physical Laboratory (NPL), London, United Kingdom Duration: 15 Sept 2011 → 16 Sept 2011

Conference

Conference	Nano Meets Spectroscopy (NMS) 2011
Country/Territory	United Kingdom
City	London
Period	15/09/11 → 16/09/11

Keywords

Raman spectroscopy
fluorescence
melanin
Thioflavin T (ThT) fluorescence

Cite this

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title = "Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T",

abstract = "Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin{\textquoteright}s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT. ",

keywords = "Raman spectroscopy, fluorescence, melanin, Thioflavin T (ThT) fluorescence",

author = "Jens Sutter and Tereza Bidlakova and Vlastimil Fidler and Jan Karolin and David Birch",

year = "2011",

month = sep,

day = "15",

language = "English",

note = "Nano Meets Spectroscopy (NMS) 2011 ; Conference date: 15-09-2011 Through 16-09-2011",

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TY - CONF

T1 - Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

AU - Sutter, Jens

AU - Bidlakova, Tereza

AU - Fidler, Vlastimil

AU - Karolin, Jan

AU - Birch, David

PY - 2011/9/15

Y1 - 2011/9/15

N2 - Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.

AB - Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.

KW - Raman spectroscopy

KW - fluorescence

KW - melanin

KW - Thioflavin T (ThT) fluorescence

M3 - Poster

T2 - Nano Meets Spectroscopy (NMS) 2011

Y2 - 15 September 2011 through 16 September 2011

ER -

Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

Abstract

Conference

Keywords

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Cite this