Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

Jens Sutter, Tereza Bidlakova, Vlastimil Fidler, Jan Karolin, David Birch

Research output: Contribution to conferencePoster

Abstract

Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.
Original languageEnglish
Publication statusPublished - 15 Sep 2011
EventNano Meets Spectroscopy (NMS) 2011 - National Physical Laboratory (NPL), London, United Kingdom
Duration: 15 Sep 201116 Sep 2011

Conference

ConferenceNano Meets Spectroscopy (NMS) 2011
CountryUnited Kingdom
CityLondon
Period15/09/1116/09/11

Keywords

  • Raman spectroscopy
  • fluorescence
  • melanin
  • Thioflavin T (ThT) fluorescence

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