Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

Jens Sutter, Tereza Bidlakova, Vlastimil Fidler, Jan Karolin, David Birch

Research output: Contribution to conferencePoster

Abstract

Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.
Original languageEnglish
Publication statusPublished - 15 Sep 2011
EventNano Meets Spectroscopy (NMS) 2011 - National Physical Laboratory (NPL), London, United Kingdom
Duration: 15 Sep 201116 Sep 2011

Conference

ConferenceNano Meets Spectroscopy (NMS) 2011
CountryUnited Kingdom
CityLondon
Period15/09/1116/09/11

Fingerprint

melanin
hair
kinetics
pigments
brain
dyes
fluorescence
synthesis
spectroscopy

Keywords

  • Raman spectroscopy
  • fluorescence
  • melanin
  • Thioflavin T (ThT) fluorescence

Cite this

Sutter, J., Bidlakova, T., Fidler, V., Karolin, J., & Birch, D. (2011). Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T. Poster session presented at Nano Meets Spectroscopy (NMS) 2011, London, United Kingdom.
Sutter, Jens ; Bidlakova, Tereza ; Fidler, Vlastimil ; Karolin, Jan ; Birch, David. / Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T. Poster session presented at Nano Meets Spectroscopy (NMS) 2011, London, United Kingdom.
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title = "Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T",
abstract = "Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.",
keywords = "Raman spectroscopy, fluorescence, melanin, Thioflavin T (ThT) fluorescence",
author = "Jens Sutter and Tereza Bidlakova and Vlastimil Fidler and Jan Karolin and David Birch",
year = "2011",
month = "9",
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note = "Nano Meets Spectroscopy (NMS) 2011 ; Conference date: 15-09-2011 Through 16-09-2011",

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Sutter, J, Bidlakova, T, Fidler, V, Karolin, J & Birch, D 2011, 'Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T' Nano Meets Spectroscopy (NMS) 2011, London, United Kingdom, 15/09/11 - 16/09/11, .

Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T. / Sutter, Jens; Bidlakova, Tereza; Fidler, Vlastimil; Karolin, Jan; Birch, David.

2011. Poster session presented at Nano Meets Spectroscopy (NMS) 2011, London, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T

AU - Sutter, Jens

AU - Bidlakova, Tereza

AU - Fidler, Vlastimil

AU - Karolin, Jan

AU - Birch, David

PY - 2011/9/15

Y1 - 2011/9/15

N2 - Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.

AB - Melanin is an important pigment present in skin, hair, the eye and the brain. Although the constituents of melanin are quite well-known, its detailed structure has so far eluded all types of spectroscopy. Here we use Thioflavin T (ThT) fluorescence to provide evidence for a sheet like structure and reveal for the first time eumelanin’s synthesis kinetics. Using the dye Congo Red, we support the kinetics seen with ThT.

KW - Raman spectroscopy

KW - fluorescence

KW - melanin

KW - Thioflavin T (ThT) fluorescence

M3 - Poster

ER -

Sutter J, Bidlakova T, Fidler V, Karolin J, Birch D. Eumelanin protomolecule sheet-like aggregation measured using Thioflavin-T. 2011. Poster session presented at Nano Meets Spectroscopy (NMS) 2011, London, United Kingdom.