Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp.

Peter Schupp, Timo Poehner, Ruangelie Edrada-Ebel, Rainer Ebel, Albrecht Berg, Victor Wray, Peter Proksch

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity.

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number2
Early online date13 Dec 2002
DOIs
Publication statusPublished - Feb 2003

Keywords

  • animals
  • anti-bacterial agents
  • anti-infective agents
  • antifungal agents
  • bacillus subtilis
  • candida albicans
  • carbolines
  • escherichia coli
  • micronesia
  • molecular structure
  • nuclear magnetic resonance, biomolecular
  • spectrometry, mass, electrospray ionization
  • staphylococcus aureus
  • urochordata

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