Estimate parameters and states of signalling pathways with unscented kalman filter

T.Y. Liu, J.F. Jia, H. Wang, H. Yue

Research output: Contribution to journalArticle

Abstract

One object of systems biology is to develop the mathematical models of biochemical networks in cell and to analysis the system dynamic properties based on these models as well as to predict the system output. However, strong nonlinearity, complexity, noisy and incomplete measurements make the parameter estimation more difficult. In this paper, Unscented Kalman filter was proposed to estimate the unknown parameters and the unobservable state variables simultaneously. TNFα mediated NF-κB signal transduction pathway was taken as an example to illustrate the effectiveness of the method. Simulation results are encouraging and show that both parameters and unobservable state variables can be estimated well.
Original languageEnglish
Pages (from-to)54-66
Number of pages13
JournalActa Biophysica Sinica
Volume23
Issue number1
Publication statusPublished - 2007

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Signal transduction
Kalman filters
Parameter estimation
Dynamical systems
Mathematical models
Systems Biology

Keywords

  • systems biology
  • biochemical networks
  • cells
  • unscented Kalman filter

Cite this

Liu, T.Y. ; Jia, J.F. ; Wang, H. ; Yue, H. / Estimate parameters and states of signalling pathways with unscented kalman filter. In: Acta Biophysica Sinica. 2007 ; Vol. 23, No. 1. pp. 54-66.
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Estimate parameters and states of signalling pathways with unscented kalman filter. / Liu, T.Y.; Jia, J.F.; Wang, H.; Yue, H.

In: Acta Biophysica Sinica, Vol. 23, No. 1, 2007, p. 54-66.

Research output: Contribution to journalArticle

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