ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae

Miguel A. Pineda, Felicity Lumb, Margaret M. Harnett, William Harnett

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Filarial nematodes cause long-term infections in hundreds of millions of people. A significant proportion of those affected develop a number of debilitating health problems but, remarkably, such infections are often unnoticed for many years. It is well known that parasitic worms modulate, yet do not completely inhibit, host immunological pathways, promoting their survival by limiting effective immune mechanisms. Such immunoregulation largely depends on molecules released by the worms, termed excretory-secretory products (ES). One of these products is the molecule ES-62, which is actively secreted by the rodent filarial nematode Acanthocheilonema viteae. ES-62 has been shown to exert anti-inflammatory actions thorough its phosphorylcholine (PC)-containing moiety on a variety of cells of the immune system, affecting intracellular signalling pathways associated with antigen receptor- and TLR-dependent responses. We summarise here how ES-62 modulates key signal transduction elements and how such immunomodulation confers protection to mice subjected to certain experimental models of inflammatory disease. Finally, we discuss recent results showing that it is possible to synthetise small molecule analogues (SMAs) that mimic the anti-inflammatory properties of ES-62, opening an exciting new drug development field in translational medicine.
LanguageEnglish
Pages1-8
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume194
Issue number1-2
Early online date23 Mar 2014
DOIs
Publication statusPublished - 1 Apr 2014

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Acanthocheilonema
Anti-Inflammatory Agents
Antigen Receptors
Translational Medical Research
Phosphorylcholine
Immunomodulation
Helminths
Infection
Immune System
Rodentia
Signal Transduction
Theoretical Models
Health
Therapeutics
Pharmaceutical Preparations

Keywords

  • cell signalling
  • ES-62
  • helminth
  • hygiene hypothesis
  • IL-17
  • immunomodulation

Cite this

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title = "ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae",
abstract = "Filarial nematodes cause long-term infections in hundreds of millions of people. A significant proportion of those affected develop a number of debilitating health problems but, remarkably, such infections are often unnoticed for many years. It is well known that parasitic worms modulate, yet do not completely inhibit, host immunological pathways, promoting their survival by limiting effective immune mechanisms. Such immunoregulation largely depends on molecules released by the worms, termed excretory-secretory products (ES). One of these products is the molecule ES-62, which is actively secreted by the rodent filarial nematode Acanthocheilonema viteae. ES-62 has been shown to exert anti-inflammatory actions thorough its phosphorylcholine (PC)-containing moiety on a variety of cells of the immune system, affecting intracellular signalling pathways associated with antigen receptor- and TLR-dependent responses. We summarise here how ES-62 modulates key signal transduction elements and how such immunomodulation confers protection to mice subjected to certain experimental models of inflammatory disease. Finally, we discuss recent results showing that it is possible to synthetise small molecule analogues (SMAs) that mimic the anti-inflammatory properties of ES-62, opening an exciting new drug development field in translational medicine.",
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ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. / Pineda, Miguel A.; Lumb, Felicity; Harnett, Margaret M.; Harnett, William.

In: Molecular and Biochemical Parasitology, Vol. 194, No. 1-2, 01.04.2014, p. 1-8.

Research output: Contribution to journalArticle

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