Abstract
A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).
| Original language | English |
|---|---|
| Pages (from-to) | 1252-1256 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 19 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 7 May 2007 |
Keywords
- enzyme responsive
- polymer hydrogel particles
- controlled release
- enzymes
- hydrogels
- biomaterials
- biomedical applications
- biomolecules
- drug delivery