Enzyme-responsive polymer hydrogel particles for controlled release

Paul D. Thornton, Robert J. Mart, Rein V. Ulijn

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

LanguageEnglish
Pages1252-1256
Number of pages6
JournalAdvanced Materials
Volume19
Issue number9
DOIs
Publication statusPublished - 7 May 2007

Fingerprint

Hydrogel
Hydrogels
Particles (particulate matter)
Polymers
Enzymes
Macromolecules
Swelling

Keywords

  • enzyme responsive
  • polymer hydrogel particles
  • controlled release
  • enzymes
  • hydrogels
  • biomaterials
  • biomedical applications
  • biomolecules
  • drug delivery

Cite this

Thornton, Paul D. ; Mart, Robert J. ; Ulijn, Rein V. / Enzyme-responsive polymer hydrogel particles for controlled release. In: Advanced Materials. 2007 ; Vol. 19, No. 9. pp. 1252-1256.
@article{c05dd4fe7c7c44c2a0e09bcda6583952,
title = "Enzyme-responsive polymer hydrogel particles for controlled release",
abstract = "A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).",
keywords = "enzyme responsive, polymer hydrogel particles, controlled release, enzymes, hydrogels, biomaterials, biomedical applications, biomolecules, drug delivery",
author = "Thornton, {Paul D.} and Mart, {Robert J.} and Ulijn, {Rein V.}",
year = "2007",
month = "5",
day = "7",
doi = "10.1002/adma.200601784",
language = "English",
volume = "19",
pages = "1252--1256",
journal = "Advanced Materials",
issn = "1521-4095",
number = "9",

}

Enzyme-responsive polymer hydrogel particles for controlled release. / Thornton, Paul D.; Mart, Robert J.; Ulijn, Rein V.

In: Advanced Materials, Vol. 19, No. 9, 07.05.2007, p. 1252-1256.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enzyme-responsive polymer hydrogel particles for controlled release

AU - Thornton, Paul D.

AU - Mart, Robert J.

AU - Ulijn, Rein V.

PY - 2007/5/7

Y1 - 2007/5/7

N2 - A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

AB - A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

KW - enzyme responsive

KW - polymer hydrogel particles

KW - controlled release

KW - enzymes

KW - hydrogels

KW - biomaterials

KW - biomedical applications

KW - biomolecules

KW - drug delivery

U2 - 10.1002/adma.200601784

DO - 10.1002/adma.200601784

M3 - Article

VL - 19

SP - 1252

EP - 1256

JO - Advanced Materials

T2 - Advanced Materials

JF - Advanced Materials

SN - 1521-4095

IS - 9

ER -