Enzyme-responsive materials: a new class of smart biomaterials

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390 Citations (Scopus)


Enzyme-responsive materials (ERMs) are a new class of smart materials that undergo macroscopic transitions when triggered by selective catalytic actions of enzymes. The use of enzymes as stimuli to trigger mechanical responses in materials opens up a number of possible applications in biology and medicine. Three different classes of ERMs are described, based on supramolecular assemblies, chemically crosslinked gels and (nanoparticle) surfaces. Potential applications in regenerative medicine, diagnostics, and drug delivery are discussed.

Original languageEnglish
Pages (from-to)2217-2225
Number of pages9
JournalJournal of Materials Chemistry
Issue number23
Early online date18 Apr 2006
Publication statusPublished - 2006


  • enzyme-responsive materials
  • new class
  • smart biomaterials


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