Enzyme-responsive hydrogels for biomedical applications

Yousef M. Y.M. Abul-Haija, Rein V. R.V. Ulijn

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.
LanguageEnglish
Title of host publicationHydrogels in Cell-Based Therapies
EditorsChe J Connon, Ian W Hamley
Place of PublicationLondon
Pages112-134
Number of pages23
DOIs
Publication statusPublished - 14 Apr 2014

Fingerprint

Hydrogels
Self assembly
Enzymes
Peptides
Molecules
Biocompatible Materials
Drug delivery
Cell culture
Amplification
Gels

Keywords

  • enzyme-responsive gels
  • small-molecule hydrogels
  • biomedical applications
  • peptide-based
  • biological selectivity
  • catalytic amplification

Cite this

Abul-Haija, Y. M. Y. M., & Ulijn, R. V. R. V. (2014). Enzyme-responsive hydrogels for biomedical applications. In C. J. Connon, & I. W. Hamley (Eds.), Hydrogels in Cell-Based Therapies (pp. 112-134). London. https://doi.org/10.1039/9781782622055-00112
Abul-Haija, Yousef M. Y.M. ; Ulijn, Rein V. R.V. / Enzyme-responsive hydrogels for biomedical applications. Hydrogels in Cell-Based Therapies. editor / Che J Connon ; Ian W Hamley. London, 2014. pp. 112-134
@inbook{82d07b6c8069406ab32ca6604f2ad33c,
title = "Enzyme-responsive hydrogels for biomedical applications",
abstract = "This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.",
keywords = "enzyme-responsive gels, small-molecule hydrogels, biomedical applications, peptide-based, biological selectivity , catalytic amplification",
author = "Abul-Haija, {Yousef M. Y.M.} and Ulijn, {Rein V. R.V.}",
year = "2014",
month = "4",
day = "14",
doi = "10.1039/9781782622055-00112",
language = "English",
isbn = "9781849737982",
pages = "112--134",
editor = "Connon, {Che J } and Hamley, { Ian W }",
booktitle = "Hydrogels in Cell-Based Therapies",

}

Abul-Haija, YMYM & Ulijn, RVRV 2014, Enzyme-responsive hydrogels for biomedical applications. in CJ Connon & IW Hamley (eds), Hydrogels in Cell-Based Therapies. London, pp. 112-134. https://doi.org/10.1039/9781782622055-00112

Enzyme-responsive hydrogels for biomedical applications. / Abul-Haija, Yousef M. Y.M.; Ulijn, Rein V. R.V.

Hydrogels in Cell-Based Therapies. ed. / Che J Connon; Ian W Hamley. London, 2014. p. 112-134.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Enzyme-responsive hydrogels for biomedical applications

AU - Abul-Haija, Yousef M. Y.M.

AU - Ulijn, Rein V. R.V.

PY - 2014/4/14

Y1 - 2014/4/14

N2 - This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.

AB - This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.

KW - enzyme-responsive gels

KW - small-molecule hydrogels

KW - biomedical applications

KW - peptide-based

KW - biological selectivity

KW - catalytic amplification

UR - http://www.scopus.com/inward/record.url?scp=84898724902&partnerID=8YFLogxK

U2 - 10.1039/9781782622055-00112

DO - 10.1039/9781782622055-00112

M3 - Chapter

SN - 9781849737982

SP - 112

EP - 134

BT - Hydrogels in Cell-Based Therapies

A2 - Connon, Che J

A2 - Hamley, Ian W

CY - London

ER -

Abul-Haija YMYM, Ulijn RVRV. Enzyme-responsive hydrogels for biomedical applications. In Connon CJ, Hamley IW, editors, Hydrogels in Cell-Based Therapies. London. 2014. p. 112-134 https://doi.org/10.1039/9781782622055-00112