Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Gabriele Rucinskaite; Sebastian A. Thompson; Sureyya Paterson; Roberto De La Rica

doi:10.1039/c7nr00298j

Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Gabriele Rucinskaite, Sebastian A. Thompson, Sureyya Paterson, Roberto De La Rica^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

45 Downloads (Pure)

Abstract

A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

Original language	English
Pages (from-to)	5404-5407
Number of pages	4
Journal	Nanoscale
Volume	9
Issue number	17
Early online date	12 Apr 2017
DOIs	https://doi.org/10.1039/c7nr00298j
Publication status	Published - 7 May 2017

Keywords

nanoparticles
cell membranes
peptides

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10.1039/c7nr00298jLicence: CC BY 3.0

Rucinskaite-etal-Nanoscale2017-Enzyme-coated-Janus-nanoparticles-that-selectively-bind-cell-receptorsFinal published version, 799 KBLicence: CC BY 3.0

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title = "Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose",

abstract = "A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).",

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AU - Thompson, Sebastian A.

AU - Paterson, Sureyya

AU - De La Rica, Roberto

PY - 2017/5/7

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KW - nanoparticles

KW - cell membranes

KW - peptides

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DO - 10.1039/c7nr00298j

M3 - Article

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Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Abstract

Keywords

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