Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Gabriele Rucinskaite, Sebastian A. Thompson, Sureyya Paterson, Roberto De La Rica

Research output: Contribution to journalArticle

10 Citations (Scopus)
23 Downloads (Pure)

Abstract

A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

Original languageEnglish
Pages (from-to)5404-5407
Number of pages4
JournalNanoscale
Volume9
Issue number17
Early online date12 Apr 2017
DOIs
Publication statusPublished - 7 May 2017

Fingerprint

Peptides
Glucose
arginyl-glycyl-aspartyl-serine
Bearings (structural)
Enzymes
Nanoparticles
Glucose Oxidase
Glucose oxidase
Cell membranes
Integrins
Substrates

Keywords

  • nanoparticles
  • cell membranes
  • peptides

Cite this

Rucinskaite, Gabriele ; Thompson, Sebastian A. ; Paterson, Sureyya ; De La Rica, Roberto. / Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose. In: Nanoscale. 2017 ; Vol. 9, No. 17. pp. 5404-5407.
@article{4ab92220f4c440d4b8db7348db9d25d1,
title = "Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose",
abstract = "A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).",
keywords = "nanoparticles, cell membranes, peptides",
author = "Gabriele Rucinskaite and Thompson, {Sebastian A.} and Sureyya Paterson and {De La Rica}, Roberto",
year = "2017",
month = "5",
day = "7",
doi = "10.1039/c7nr00298j",
language = "English",
volume = "9",
pages = "5404--5407",
journal = "Nanoscale",
issn = "2040-3364",
number = "17",

}

Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose. / Rucinskaite, Gabriele; Thompson, Sebastian A.; Paterson, Sureyya; De La Rica, Roberto.

In: Nanoscale, Vol. 9, No. 17, 07.05.2017, p. 5404-5407.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

AU - Rucinskaite, Gabriele

AU - Thompson, Sebastian A.

AU - Paterson, Sureyya

AU - De La Rica, Roberto

PY - 2017/5/7

Y1 - 2017/5/7

N2 - A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

AB - A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

KW - nanoparticles

KW - cell membranes

KW - peptides

UR - http://www.scopus.com/inward/record.url?scp=85021773733&partnerID=8YFLogxK

U2 - 10.1039/c7nr00298j

DO - 10.1039/c7nr00298j

M3 - Article

VL - 9

SP - 5404

EP - 5407

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 17

ER -