Enzymatic optical resolution via acylation-hydrolysis on a solid support

R V Ulijn, N Bisek, S L Flitsch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number4
Early online date28 Jan 2003
DOIs
Publication statusPublished - 21 Feb 2003

Keywords

  • enzymatic optical resolution
  • acylation-hydrolysis
  • solid support

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