Enzymatic optical resolution via acylation-hydrolysis on a solid support

R V  Ulijn; N  Bisek; S L  Flitsch

doi:10.1039/b211887d

Enzymatic optical resolution via acylation-hydrolysis on a solid support

R V Ulijn, N Bisek, S L Flitsch

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

Original language	English
Pages (from-to)	621-622
Number of pages	2
Journal	Organic and Biomolecular Chemistry
Volume	1
Issue number	4
Early online date	28 Jan 2003
DOIs	https://doi.org/10.1039/b211887d
Publication status	Published - 21 Feb 2003

Keywords

enzymatic optical resolution
acylation-hydrolysis
solid support

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10.1039/b211887d

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title = "Enzymatic optical resolution via acylation-hydrolysis on a solid support",

abstract = "By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.",

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AU - Ulijn, R V

AU - Bisek, N

AU - Flitsch, S L

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Y1 - 2003/2/21

N2 - By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

AB - By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

KW - enzymatic optical resolution

KW - acylation-hydrolysis

KW - solid support

U2 - 10.1039/b211887d

DO - 10.1039/b211887d

M3 - Article

SN - 1477-0520

VL - 1

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EP - 622

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 4

ER -

Enzymatic optical resolution via acylation-hydrolysis on a solid support

Abstract

Keywords

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