Enzymatic optical resolution via acylation-hydrolysis on a solid support

R V Ulijn, N Bisek, S L Flitsch

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalOrganic and Biomolecular Chemistry
Issue number4
Early online date28 Jan 2003
Publication statusPublished - 21 Feb 2003


  • enzymatic optical resolution
  • acylation-hydrolysis
  • solid support

Fingerprint Dive into the research topics of 'Enzymatic optical resolution via acylation-hydrolysis on a solid support'. Together they form a unique fingerprint.

Cite this