Enzymatic optical resolution via acylation-hydrolysis on a solid support

R V Ulijn, N Bisek, S L Flitsch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis-hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

LanguageEnglish
Pages621-622
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number4
Early online date28 Jan 2003
DOIs
Publication statusPublished - 21 Feb 2003

Fingerprint

acylation
Acylation
amino acids
hydrolysis
Hydrolysis
Thermolysin
Amino Acids
Dipeptides
Amides
amides
synthesis

Keywords

  • enzymatic optical resolution
  • acylation-hydrolysis
  • solid support

Cite this

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Enzymatic optical resolution via acylation-hydrolysis on a solid support. / Ulijn, R V ; Bisek, N ; Flitsch, S L .

In: Organic and Biomolecular Chemistry, Vol. 1, No. 4, 21.02.2003, p. 621-622.

Research output: Contribution to journalArticle

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AU - Bisek, N

AU - Flitsch, S L

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KW - solid support

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