Abstract
Purpose of Review -- In this review, we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to explore the role metabolomics can play in identifying exposures, assessing the interplay between co-exposures, and the development of personalized therapeutic interventions.
Recent Findings -- Approximately 10% of CRC cases can be explained by germ-line mutations, whereas the prevailing majority is caused by an initiating exposure event occurring decades prior to diagnosis. Recent research has shown that dietary metabolites are linked to both a procarcinogenic or protective environment in the colon, which is modulated by the microbiome. In addition, excessive alcohol has been shown to increase the risk of CRC and is dependent on diet, the response of microbiome, and genetic polymorphisms within the folate and alcohol metabolic pathways. Metabolomics cannot only be used to identify this modulation of host metabolism, which could affect not only the progression of the tumors but also response to targeted therapeutics.
Summary -- This review highlights the current understanding of the multifaceted etiology and mechanisms of CRC development but also where the field of metabolomics can contribute to a greater understanding of exposures in CRC.
Recent Findings -- Approximately 10% of CRC cases can be explained by germ-line mutations, whereas the prevailing majority is caused by an initiating exposure event occurring decades prior to diagnosis. Recent research has shown that dietary metabolites are linked to both a procarcinogenic or protective environment in the colon, which is modulated by the microbiome. In addition, excessive alcohol has been shown to increase the risk of CRC and is dependent on diet, the response of microbiome, and genetic polymorphisms within the folate and alcohol metabolic pathways. Metabolomics cannot only be used to identify this modulation of host metabolism, which could affect not only the progression of the tumors but also response to targeted therapeutics.
Summary -- This review highlights the current understanding of the multifaceted etiology and mechanisms of CRC development but also where the field of metabolomics can contribute to a greater understanding of exposures in CRC.
| Original language | English |
|---|---|
| Pages (from-to) | 114-125 |
| Number of pages | 12 |
| Journal | Current Pharmacology Reports |
| Volume | 3 |
| Issue number | 3 |
| Early online date | 7 Apr 2017 |
| DOIs | |
| Publication status | Published - 30 Jun 2017 |
Keywords
- toxicology
- cancer
- public health