Environmental influences in the etiology of colorectal cancer: the premise of metabolomics

Nicholas Rattray, Georgia Charkoftaki, Zahra Rattray, James E. Hansen, Vasilis Vasilou, Caroline H. Johnson

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Purpose of Review -- In this review, we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to explore the role metabolomics can play in identifying exposures, assessing the interplay between co-exposures, and the development of personalized therapeutic interventions.

Recent Findings -- Approximately 10% of CRC cases can be explained by germ-line mutations, whereas the prevailing majority is caused by an initiating exposure event occurring decades prior to diagnosis. Recent research has shown that dietary metabolites are linked to both a procarcinogenic or protective environment in the colon, which is modulated by the microbiome. In addition, excessive alcohol has been shown to increase the risk of CRC and is dependent on diet, the response of microbiome, and genetic polymorphisms within the folate and alcohol metabolic pathways. Metabolomics cannot only be used to identify this modulation of host metabolism, which could affect not only the progression of the tumors but also response to targeted therapeutics.

Summary -- This review highlights the current understanding of the multifaceted etiology and mechanisms of CRC development but also where the field of metabolomics can contribute to a greater understanding of exposures in CRC.
Original languageEnglish
Pages (from-to)114-125
Number of pages12
JournalCurrent Pharmacology Reports
Volume3
Issue number3
Early online date7 Apr 2017
DOIs
Publication statusPublished - 30 Jun 2017

Keywords

  • toxicology
  • cancer
  • public health

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