Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

M. A. Rubinson; J. A. Parkinson; M. P. Evstigneev

doi:10.1016/j.cplett.2015.02.006

Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

M. A. Rubinson, J. A. Parkinson, M. P. Evstigneev^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

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Abstract

The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed.

Original language	English
Pages (from-to)	12-14
Number of pages	3
Journal	Chemical Physics Letters
Volume	624
Early online date	9 Feb 2015
DOIs	https://doi.org/10.1016/j.cplett.2015.02.006
Publication status	Published - 16 Mar 2015

Keywords

drug–DNA binding
entropic preference
DNA minor groove binders
MGB ligands

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10.1016/j.cplett.2015.02.006

Rubinson-etal-CPL2015-Entropic-binding-mode-preference-in-cooperative-homo-dimeric-drug-DNA-recognitionAccepted author manuscript, 639 KBLicence: CC BY-NC-ND 4.0

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abstract = "The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed.",

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AU - Rubinson, M. A.

AU - Parkinson, J. A.

AU - Evstigneev, M. P.

PY - 2015/3/16

Y1 - 2015/3/16

N2 - The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed.

AB - The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed.

KW - drug–DNA binding

KW - entropic preference

KW - DNA minor groove binders

KW - MGB ligands

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JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

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Keywords

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