Enhanced working memory binding by direct electrical stimulation of the parietal cortex

Agustina Birba, Eugenia Hesse, Lucas Sedeño, Ezequiel P. Mikulan, María Del C. García, Juan Ávalos, Federico Adolfi, Agustina Legaz, Tristán A. Bekinschtein, Máximo Zimerman, Mario Parra, Adolfo M. García, Agustín Ibáñez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and

LanguageEnglish
Article number178
Number of pages7
JournalFrontiers in Aging Neuroscience
Volume9
DOIs
Publication statusPublished - 8 Jun 2017

Fingerprint

Parietal Lobe
Short-Term Memory
Electric Stimulation
Alzheimer Disease
Memory Disorders
Prodromal Symptoms
Deep Brain Stimulation
Brain
Electrodes
Research Design
Biomarkers
Control Groups

Keywords

  • working memory binding
  • Alzheimer's disease (AD)
  • direct electrical stimulation
  • short term memory

Cite this

Birba, A., Hesse, E., Sedeño, L., Mikulan, E. P., García, M. D. C., Ávalos, J., ... Ibáñez, A. (2017). Enhanced working memory binding by direct electrical stimulation of the parietal cortex. Frontiers in Aging Neuroscience, 9, [178]. https://doi.org/10.3389/fnagi.2017.00178
Birba, Agustina ; Hesse, Eugenia ; Sedeño, Lucas ; Mikulan, Ezequiel P. ; García, María Del C. ; Ávalos, Juan ; Adolfi, Federico ; Legaz, Agustina ; Bekinschtein, Tristán A. ; Zimerman, Máximo ; Parra, Mario ; García, Adolfo M. ; Ibáñez, Agustín. / Enhanced working memory binding by direct electrical stimulation of the parietal cortex. In: Frontiers in Aging Neuroscience. 2017 ; Vol. 9.
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Birba, A, Hesse, E, Sedeño, L, Mikulan, EP, García, MDC, Ávalos, J, Adolfi, F, Legaz, A, Bekinschtein, TA, Zimerman, M, Parra, M, García, AM & Ibáñez, A 2017, 'Enhanced working memory binding by direct electrical stimulation of the parietal cortex' Frontiers in Aging Neuroscience, vol. 9, 178. https://doi.org/10.3389/fnagi.2017.00178

Enhanced working memory binding by direct electrical stimulation of the parietal cortex. / Birba, Agustina; Hesse, Eugenia; Sedeño, Lucas; Mikulan, Ezequiel P.; García, María Del C.; Ávalos, Juan; Adolfi, Federico; Legaz, Agustina; Bekinschtein, Tristán A.; Zimerman, Máximo; Parra, Mario; García, Adolfo M.; Ibáñez, Agustín.

In: Frontiers in Aging Neuroscience, Vol. 9, 178, 08.06.2017.

Research output: Contribution to journalArticle

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AU - Hesse, Eugenia

AU - Sedeño, Lucas

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AU - García, María Del C.

AU - Ávalos, Juan

AU - Adolfi, Federico

AU - Legaz, Agustina

AU - Bekinschtein, Tristán A.

AU - Zimerman, Máximo

AU - Parra, Mario

AU - García, Adolfo M.

AU - Ibáñez, Agustín

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