Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

S Currie; G L Smith

doi:10.1016/S0008-6363(98)00241-7

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

S Currie, G L Smith

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.

Original language	English
Pages (from-to)	135-146
Number of pages	12
Journal	Cardiovascular Research
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/S0008-6363(98)00241-7
Publication status	Published - Jan 1999

Keywords

heart failure
rabbit
phospholamban
phosphorylation
sarcoplasmic reticulum
Ca2+ uptake

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10.1016/S0008-6363(98)00241-7

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title = "Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure",

abstract = "To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.",

keywords = "heart failure, rabbit, phospholamban, phosphorylation, sarcoplasmic reticulum, Ca2+ uptake",

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year = "1999",

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AU - Currie, S

AU - Smith, G L

PY - 1999/1

Y1 - 1999/1

N2 - To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.

AB - To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.

KW - heart failure

KW - rabbit

KW - phospholamban

KW - phosphorylation

KW - sarcoplasmic reticulum

KW - Ca2+ uptake

U2 - 10.1016/S0008-6363(98)00241-7

DO - 10.1016/S0008-6363(98)00241-7

M3 - Article

C2 - 10325961

SN - 0008-6363

VL - 41

SP - 135

EP - 146

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

Abstract

Keywords

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