Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

S Currie, G L Smith

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Abstract

To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.
LanguageEnglish
Pages135-146
Number of pages12
JournalCardiovascular Research
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 1999

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Sarcoplasmic Reticulum Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Down-Regulation
Heart Failure
Phosphorylation
Rabbits
Proteins
phospholamban

Keywords

  • heart failure
  • rabbit
  • phospholamban
  • phosphorylation
  • sarcoplasmic reticulum
  • Ca2+ uptake

Cite this

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title = "Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure",
abstract = "To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.",
keywords = "heart failure, rabbit, phospholamban, phosphorylation, sarcoplasmic reticulum, Ca2+ uptake",
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T1 - Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

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AU - Smith, G L

PY - 1999/1

Y1 - 1999/1

N2 - To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.

AB - To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.

KW - heart failure

KW - rabbit

KW - phospholamban

KW - phosphorylation

KW - sarcoplasmic reticulum

KW - Ca2+ uptake

U2 - 10.1016/S0008-6363(98)00241-7

DO - 10.1016/S0008-6363(98)00241-7

M3 - Article

VL - 41

SP - 135

EP - 146

JO - Cardiovascular Research

T2 - Cardiovascular Research

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SN - 0008-6363

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