Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

S Currie, G L Smith

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Abstract

To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model of heart failure. Furthermore, to correlate these parameters with the rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesicles.
Original languageEnglish
Pages (from-to)135-146
Number of pages12
JournalCardiovascular Research
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 1999

Keywords

  • heart failure
  • rabbit
  • phospholamban
  • phosphorylation
  • sarcoplasmic reticulum
  • Ca2+ uptake

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