Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application

Julia C Bartsch, Pawel Fidzinski, Jojanneke HJ Huck, Heide Hörtnagl, Richard Kovács, Agustin Liotta, Josef Priller, Christian Wozny, Joachim Behr

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dopaminergic hyperfunction and N-methyl-D-aspartate receptor (NMDAR) hypofunction have both been implicated in psychosis. Dopamine-releasing drugs and NMDAR antagonists replicate symptoms associated with psychosis in healthy humans and exacerbate symptoms in patients with schizophrenia. Though hippocampal dysfunction contributes to psychosis, the impact of NMDAR hypofunction on hippocampal plasticity remains poorly understood. Here, we used an NMDAR antagonist rodent model of psychosis to investigate hippocampal long-term potentiation (LTP). We found that single systemic NMDAR antagonism results in a region-specific, presynaptic LTP at hippocampal CA1-subiculum synapses that is induced by activation of D1/D5 dopamine receptors and modulated by L-type voltage-gated Ca(2+) channels. Thereby, our findings may provide a cellular mechanism how NMDAR antagonism can lead to an enhanced hippocampal output causing activation of the hippocampus-ventral tegmental area-loop and overdrive of the dopamine system.

LanguageEnglish
Pages987-995
Number of pages9
JournalNeuropsychopharmacology
Volume40
Issue number4
Early online date15 Oct 2014
DOIs
Publication statusPublished - 1 Mar 2015

Fingerprint

Dizocilpine Maleate
N-Methyl-D-Aspartate Receptors
Dopamine
Psychotic Disorders
Long-Term Potentiation
Hippocampus
Dopamine D5 Receptors
Dopamine D1 Receptors
Dopamine Agents
Ventral Tegmental Area
Synapses
Rodentia
Schizophrenia

Keywords

  • dopaminergic hyperfunction
  • psychosis
  • hippocampal dysfunction

Cite this

Bartsch, J. C., Fidzinski, P., Huck, J. HJ., Hörtnagl, H., Kovács, R., Liotta, A., ... Behr, J. (2015). Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application. Neuropsychopharmacology, 40(4), 987-995. https://doi.org/10.1038/npp.2014.276
Bartsch, Julia C ; Fidzinski, Pawel ; Huck, Jojanneke HJ ; Hörtnagl, Heide ; Kovács, Richard ; Liotta, Agustin ; Priller, Josef ; Wozny, Christian ; Behr, Joachim. / Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application. In: Neuropsychopharmacology. 2015 ; Vol. 40, No. 4. pp. 987-995.
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Bartsch, JC, Fidzinski, P, Huck, JHJ, Hörtnagl, H, Kovács, R, Liotta, A, Priller, J, Wozny, C & Behr, J 2015, 'Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application' Neuropsychopharmacology, vol. 40, no. 4, pp. 987-995. https://doi.org/10.1038/npp.2014.276

Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application. / Bartsch, Julia C; Fidzinski, Pawel; Huck, Jojanneke HJ; Hörtnagl, Heide; Kovács, Richard; Liotta, Agustin; Priller, Josef; Wozny, Christian; Behr, Joachim.

In: Neuropsychopharmacology, Vol. 40, No. 4, 01.03.2015, p. 987-995.

Research output: Contribution to journalArticle

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Bartsch JC, Fidzinski P, Huck JHJ, Hörtnagl H, Kovács R, Liotta A et al. Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application. Neuropsychopharmacology. 2015 Mar 1;40(4):987-995. https://doi.org/10.1038/npp.2014.276