Abstract
Language | English |
---|---|
Pages | 1140-6 |
Number of pages | 7 |
Journal | Experimental Hematology |
Volume | 33 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 |
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Keywords
- antigens
- antineoplastic agents
- apoptosis
- bryostatins
- drug antagonism
- hematopoietic stem cells
- leukemia
- macrolides
- piperazines
- protein kinase C
- pyrimidines
Cite this
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Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate. / Jørgensen, Heather G; Allan, Elaine K; Mountford, Joanne C; Richmond, Linda; Harrison, Simon; Elliott, Moira A; Holyoake, Tessa L.
In: Experimental Hematology , Vol. 33, No. 10, 2005, p. 1140-6.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate
AU - Jørgensen, Heather G
AU - Allan, Elaine K
AU - Mountford, Joanne C
AU - Richmond, Linda
AU - Harrison, Simon
AU - Elliott, Moira A
AU - Holyoake, Tessa L
PY - 2005
Y1 - 2005
N2 - In chronic myeloid leukemia (CML), imatinib mesylate (IM; Gleevec, Glivec) induces a G0/G1 cell-cycle block in total CD34(+) cells without causing significant apoptosis. Bryostatin-1 (bryo), a protein kinase C (PKC) modulator, was investigated for its ability to increase IM-mediated apoptosis either through induction of cycling of G0/G1 Ph(+) cells or antagonism of the IM-induced cell-cycle block.
AB - In chronic myeloid leukemia (CML), imatinib mesylate (IM; Gleevec, Glivec) induces a G0/G1 cell-cycle block in total CD34(+) cells without causing significant apoptosis. Bryostatin-1 (bryo), a protein kinase C (PKC) modulator, was investigated for its ability to increase IM-mediated apoptosis either through induction of cycling of G0/G1 Ph(+) cells or antagonism of the IM-induced cell-cycle block.
KW - antigens
KW - antineoplastic agents
KW - apoptosis
KW - bryostatins
KW - drug antagonism
KW - hematopoietic stem cells
KW - leukemia
KW - macrolides
KW - piperazines
KW - protein kinase C
KW - pyrimidines
U2 - 10.1016/j.exphem.2005.05.020
DO - 10.1016/j.exphem.2005.05.020
M3 - Article
VL - 33
SP - 1140
EP - 1146
JO - Experimental Hematology
T2 - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 10
ER -