Abstract
In chronic myeloid leukemia (CML), imatinib mesylate (IM; Gleevec, Glivec) induces a G0/G1 cell-cycle block in total CD34(+) cells without causing significant apoptosis. Bryostatin-1 (bryo), a protein kinase C (PKC) modulator, was investigated for its ability to increase IM-mediated apoptosis either through induction of cycling of G0/G1 Ph(+) cells or antagonism of the IM-induced cell-cycle block.
Original language | English |
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Pages (from-to) | 1140-6 |
Number of pages | 7 |
Journal | Experimental Hematology |
Volume | 33 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 |
Keywords
- antigens
- antineoplastic agents
- apoptosis
- bryostatins
- drug antagonism
- hematopoietic stem cells
- leukemia
- macrolides
- piperazines
- protein kinase C
- pyrimidines