Engineering silica particles as oral drug delivery vehicles

S.P. Rigby, M. Fairhead, Christopher F. van der Walle

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Porous silica particles are emerging as complementary systems to polyester microspheres for the encapsulation and controlled delivery of small-organic drugs. Their recent application in pharmaceutics is strengthened by well-established characterization and synthetic routes from the chemical engineering sciences. Silica is an interesting scaffold material for the encapsulation of organic molecules. It can be formed into hierarchical structures over a wide range of length scales and interconnectivities. Encapsulation can therefore be tailored not only to the drug but the desired release properties. In addition to surfactant-templating of hierarchical silica structures, polypeptides from marine organisms may offer biological routes to novel silica materials. Silica sol-gels have also been evaluated as delivery vehicles, particularly with regard to generating hybrid systems with mesoporous silica or composite xerogels. This review will first focus on the detailed characterisation of pore size and structure of mesoporous silica with regards water penetration and drug diffusion. We then describe the pharmaceutical applications of silica materials with regard to improving oral bioavailability, multiparticulate systems for gastroretention or sustained release, composite xerogels and in vivo biocompatibility.
LanguageEnglish
Pages1821-1831
Number of pages10
JournalCurrent Pharmaceutical Design
Volume14
Issue number18
Publication statusPublished - Jun 2008

Fingerprint

Silicon Dioxide
Pharmaceutical Preparations
Chemical Engineering
Aquatic Organisms
Polyesters
Silica Gel
Polymethyl Methacrylate
Microspheres
Surface-Active Agents
Biological Availability
Peptides
Water

Keywords

  • mesoporous silica
  • pore size
  • xerogels
  • dissolution
  • drug release
  • passive targeting
  • biosilica

Cite this

Rigby, S. P., Fairhead, M., & van der Walle, C. F. (2008). Engineering silica particles as oral drug delivery vehicles. Current Pharmaceutical Design, 14(18), 1821-1831.
Rigby, S.P. ; Fairhead, M. ; van der Walle, Christopher F. / Engineering silica particles as oral drug delivery vehicles. In: Current Pharmaceutical Design. 2008 ; Vol. 14, No. 18. pp. 1821-1831.
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Rigby, SP, Fairhead, M & van der Walle, CF 2008, 'Engineering silica particles as oral drug delivery vehicles' Current Pharmaceutical Design, vol. 14, no. 18, pp. 1821-1831.

Engineering silica particles as oral drug delivery vehicles. / Rigby, S.P.; Fairhead, M.; van der Walle, Christopher F.

In: Current Pharmaceutical Design, Vol. 14, No. 18, 06.2008, p. 1821-1831.

Research output: Contribution to journalArticle

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Rigby SP, Fairhead M, van der Walle CF. Engineering silica particles as oral drug delivery vehicles. Current Pharmaceutical Design. 2008 Jun;14(18):1821-1831.