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Abstract
Wet milling coupled with crystallisation has considerable potential to deliver enhanced control over particle attributes. The effect of process conditions and wet mill configuration on particle size, shape and surface energy has been investigated on acetaminophen using a seeded cooling crystallisation coupled with a wet mill unit generating size controlled acetaminophen crystals through an interchangeable rotor-tooth configuration. The integrated wet milling crystallisation platform incorporates inline focused beam reflectance measurement (FBRM) and particle vision measurement (PVM) for in-depth understanding of particle behaviour under high-shear conditions. We used a recently developed computational tool for converting chord length distribution (CLD) from FBRM to particle size distribution (PSD) to obtain quantitative insight into the effect of the competing mechanisms of size reduction and growth in a wet milling seeded crystallisation process for acetaminophen. The novelty of our wet milling crystallisation approach is in delivery of consistent surface energies across a range of particle sizes. This highlights the potential to engineer desirable particle attributes through a carefully designed, highly intensified crystallisation process.
Original language | English |
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Pages (from-to) | 201-211 |
Number of pages | 11 |
Journal | International Journal of Pharmaceutics |
Volume | 554 |
Early online date | 31 Oct 2018 |
DOIs | |
Publication status | Published - 10 Jan 2019 |
Keywords
- wet milling
- crystallisation
- breakage
- CLD to PSD inversion
- particle size
- surface heterogeneity
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Dive into the research topics of 'Engineering of acetaminophen particle attributes using a wet milling crystallisation platform'. Together they form a unique fingerprint.Projects
- 1 Finished
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Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Ahmed, Bilal
Florence, A., Sefcik, J. & Ahmed, B.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/14 → 9/10/19
Project: Research Studentship - Internally Allocated
Datasets
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Data for: "Engineering of Acetaminophen Particle Attributes Using a Wet Milling Crystallisation Platform"
Ahmed, B. (Creator), Brown, C. (Creator), McGlone, T. (Contributor), Bowering, D. (Contributor), Sefcik, J. (Contributor) & Florence, A. (Owner), University of Strathclyde, 29 Nov 2018
DOI: 10.15129/85491e74-2d64-4c01-8507-5de1afbfce70
Dataset