@inproceedings{ac579bd7974b443f9f945a590a5b4f61,
title = "Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering",
abstract = "We report a novel nanophotonic biosensor surface capable of both colorimetric detection and Raman-scattered detection of DNA infection markers at extreme sensitivities. Combining direct-write lithography, dip-pen nanolithography based DNA patterning, and molecular self-assembly, we create molecularly-active plasmonic nanostructures onto which metallic nanoparticles are located via DNA-hybridization. Arraying these structures enables optical surfaces that change state when contacted by specific DNA sequences; shifting the surface color while simultaneously generating strong Raman-scattering signals. Patterning the DNA markers onto the plasmonic surface as micro-scale symbols results in easily identifiable color shifts, making this technique applicable to multiplexed lab-on-a-chip and point-of-care diagnostic applications.",
keywords = "biosensors, colorimetry, dip-pen nanolithography, DNA assembly, electron-beam lithography, naked-eye detection, plasmonics, surface enhanced Raman spectroscopy, lab-on-a-chip, scanning probe lithography, molecular self-assembly, multiplexing",
author = "Esmaeil Heydari and Samuel Mabbott and David Thompson and Duncan Graham and Cooper, {Jonathan M.} and Clark, {Alasdair W.}",
note = "Heydari, Esmaeil; Mabbott, Samuel; Thompson, David; Graham, Duncan; Cooper, Jonathan M.; Clark, Alasdair W. {"}Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering.{"} Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. ed. / Alexander N. Cartwright; Dan V. Nicolau. Proceedings of Spie Vol. 9721 Bellingham WA : SPIE, 2016. 972105, 2016. Copyright 2016 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.2209108",
year = "2016",
doi = "10.1117/12.2209108",
language = "English",
isbn = "9781628419559",
volume = "9721",
series = "Proceedings of Spie",
publisher = "SPIE",
editor = "Cartwright, {Alexander N.} and Nicolau, {Dan V.}",
booktitle = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII",
}