Endothelial signalling operates on a small-world, scale-free network

Research output: Contribution to journalMeeting abstract


The endothelium is the single layer of cells lining all blood vessels and acts as a central control hub to regulate multiple cardiovascular functions in response to hundreds of physiological stimuli. The endothelium controls vascular contractility, hemostasis, and inflammation and regulate the exchange of oxygen, nutrients, and waste products between circulating blood and tissue. To control each function, the endothelium must process numerous requests from multiple sources. A well-developed but poorly understood communication system operates between cells to integrate multiple lines of information and coordinate endothelial responses. In this study, the nature of the communication network has been addressed using single-cell Ca2+imaging across thousands of endothelial cells in intact blood vessels
Original languageEnglish
Article numberA 07-28
Pages (from-to)550-551
Number of pages2
JournalActa Physiologica
Issue numberSupp. 725
Publication statusPublished - 30 Sept 2022


  • blood vessels
  • endothelial cells
  • cardiovascular function


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