Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis

T Hoehn, M William, A R McPhaden, H Stannigel, E Mayatepek, R M Wadsworth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Abnormal growth and development of lymphatic pulmonary structures leads to severe hypoxia in congenital pulmonary lymphangiectasis (CPL).

This case study aims to determine the cellular source and topographical distribution of the nitric oxide synthases in CPL. It studies the postmortem tissue of a term newborn with the clinical course and histological findings of CPL and three controls without pulmonary pathology.

It was found that endothelial cells of pulmonary arteries and lymphatic structures stained significantly more for endothelial nitric oxide synthase protein in the CPL patient compared to the controls.

The authors conclude that synthesis of endothelial nitric oxide synthase is upregulated in vascular and lymphatic endothelial cells in congenital pulmonary lymphanglectasis.

LanguageEnglish
Pages1311-1315
Number of pages5
JournalEuropean Respiratory Journal
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Lymphangiectasis
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
Nitric Oxide Synthase Type II
Lung
Endothelial Cells
Growth and Development
Nitric Oxide Synthase
Pulmonary Artery
Newborn Infant
Pathology

Keywords

  • endothelial cells
  • endothelial nitric oxide synthase
  • inducible nitric oxide synthase
  • inhaled nitric oxide
  • newborn
  • nitrotyrosine
  • cystic lymphangiectasis
  • hypertension
  • cells

Cite this

Hoehn, T., William, M., McPhaden, A. R., Stannigel, H., Mayatepek, E., & Wadsworth, R. M. (2006). Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. European Respiratory Journal, 27(6), 1311-1315. https://doi.org/10.1183/09031936.06.00082705
Hoehn, T ; William, M ; McPhaden, A R ; Stannigel, H ; Mayatepek, E ; Wadsworth, R M . / Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. In: European Respiratory Journal. 2006 ; Vol. 27, No. 6. pp. 1311-1315.
@article{e530dc80f3c94c5a890d5b6af0c83c2b,
title = "Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis",
abstract = "Abnormal growth and development of lymphatic pulmonary structures leads to severe hypoxia in congenital pulmonary lymphangiectasis (CPL).This case study aims to determine the cellular source and topographical distribution of the nitric oxide synthases in CPL. It studies the postmortem tissue of a term newborn with the clinical course and histological findings of CPL and three controls without pulmonary pathology.It was found that endothelial cells of pulmonary arteries and lymphatic structures stained significantly more for endothelial nitric oxide synthase protein in the CPL patient compared to the controls.The authors conclude that synthesis of endothelial nitric oxide synthase is upregulated in vascular and lymphatic endothelial cells in congenital pulmonary lymphanglectasis.",
keywords = "endothelial cells, endothelial nitric oxide synthase, inducible nitric oxide synthase, inhaled nitric oxide, newborn, nitrotyrosine, cystic lymphangiectasis, hypertension, cells",
author = "T Hoehn and M William and McPhaden, {A R} and H Stannigel and E Mayatepek and Wadsworth, {R M}",
year = "2006",
month = "6",
doi = "10.1183/09031936.06.00082705",
language = "English",
volume = "27",
pages = "1311--1315",
journal = "European Respiratory Journal",
issn = "0903-1936",
number = "6",

}

Hoehn, T, William, M, McPhaden, AR, Stannigel, H, Mayatepek, E & Wadsworth, RM 2006, 'Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis' European Respiratory Journal, vol. 27, no. 6, pp. 1311-1315. https://doi.org/10.1183/09031936.06.00082705

Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. / Hoehn, T ; William, M ; McPhaden, A R ; Stannigel, H ; Mayatepek, E ; Wadsworth, R M .

In: European Respiratory Journal, Vol. 27, No. 6, 06.2006, p. 1311-1315.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis

AU - Hoehn, T

AU - William, M

AU - McPhaden, A R

AU - Stannigel, H

AU - Mayatepek, E

AU - Wadsworth, R M

PY - 2006/6

Y1 - 2006/6

N2 - Abnormal growth and development of lymphatic pulmonary structures leads to severe hypoxia in congenital pulmonary lymphangiectasis (CPL).This case study aims to determine the cellular source and topographical distribution of the nitric oxide synthases in CPL. It studies the postmortem tissue of a term newborn with the clinical course and histological findings of CPL and three controls without pulmonary pathology.It was found that endothelial cells of pulmonary arteries and lymphatic structures stained significantly more for endothelial nitric oxide synthase protein in the CPL patient compared to the controls.The authors conclude that synthesis of endothelial nitric oxide synthase is upregulated in vascular and lymphatic endothelial cells in congenital pulmonary lymphanglectasis.

AB - Abnormal growth and development of lymphatic pulmonary structures leads to severe hypoxia in congenital pulmonary lymphangiectasis (CPL).This case study aims to determine the cellular source and topographical distribution of the nitric oxide synthases in CPL. It studies the postmortem tissue of a term newborn with the clinical course and histological findings of CPL and three controls without pulmonary pathology.It was found that endothelial cells of pulmonary arteries and lymphatic structures stained significantly more for endothelial nitric oxide synthase protein in the CPL patient compared to the controls.The authors conclude that synthesis of endothelial nitric oxide synthase is upregulated in vascular and lymphatic endothelial cells in congenital pulmonary lymphanglectasis.

KW - endothelial cells

KW - endothelial nitric oxide synthase

KW - inducible nitric oxide synthase

KW - inhaled nitric oxide

KW - newborn

KW - nitrotyrosine

KW - cystic lymphangiectasis

KW - hypertension

KW - cells

U2 - 10.1183/09031936.06.00082705

DO - 10.1183/09031936.06.00082705

M3 - Article

VL - 27

SP - 1311

EP - 1315

JO - European Respiratory Journal

T2 - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 6

ER -