End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17

Richard Pebody, Fiona Warburton, Joanna Ellis, Nick Andrews, Alison Potts, Simon Cottrell, Arlene Reynolds, Rory Gunson, Catherine Thompson, Monica Galiano, Chris Robertson, Naomh Gallagher, Mary Sinnathamby, Ivelina Yonova, Ana Correa, Catherine Moore, Muhammad Sartaj, Simon de Lusignan, Jim McMenamin, Maria Zambon

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Abstract

Introduction The United Kingdom is in the fourth season of introducing a universal childhood influenza vaccine programme. The 2016/17 season saw early influenza A(H3N2) virus circulation with care home outbreaks and increased excess mortality particularly in those 65 years or older. Virus characterisation data indicated emergence of genetic clusters within the A(H3N2) 3C.2a group which the 2016/17 vaccine strain belonged to. Methods: The test-negative case-control (TNCC) design was used to estimate vaccine effectiveness (VE) against laboratory confirmed influenza in primary care. Results: Adjusted end-of-season vaccine effectiveness (aVE) estimates were 39.8% (95% confidence interval (CI): 23.1 to 52.8) against all influenza and 40.6% (95% CI: 19.0 to 56.3) in 18-64-year-olds, but no significant aVE in ≥ 65-year-olds. aVE was 65.8% (95% CI: 30.3 to 83.2) for 2-17-year-olds receiving quadrivalent live attenuated influenza vaccine. Discussion: The findings continue to provide support for the ongoing roll-out of the paediatric vaccine programme, with a need for ongoing evaluation. The importance of effective interventions to protect the ≥ 65-year-olds remains.

Original languageEnglish
JournalEurosurveillance
Volume22
Issue number44
DOIs
Publication statusPublished - 2 Nov 2017

Keywords

  • adolescent
  • adult
  • aged
  • aged, 80 and over
  • case-control studies
  • child
  • child, preschool
  • disease outbreaks
  • female
  • humans
  • immunization programs
  • infant
  • influenza A virus
  • influenza B virus
  • influenza Vaccines
  • influenza, human
  • male
  • middle aged
  • outcome assessment (health care)
  • population surveillance
  • primary health care
  • reverse transcriptase polymerase chain reaction
  • sensitivity and specificity
  • sentinel surveillance
  • United Kingdom
  • vaccination
  • vaccine potency
  • vaccines, attenuated
  • young adult

Cite this

Pebody, R., Warburton, F., Ellis, J., Andrews, N., Potts, A., Cottrell, S., Reynolds, A., Gunson, R., Thompson, C., Galiano, M., Robertson, C., Gallagher, N., Sinnathamby, M., Yonova, I., Correa, A., Moore, C., Sartaj, M., de Lusignan, S., McMenamin, J., & Zambon, M. (2017). End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17. Eurosurveillance, 22(44). https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00306