Encephalitis in mice with congenital ocular toxoplasmosis

D.I. Graham, J. Hay, W.M. Hutchison, J.C. Siim

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Abstract

The brains of mice with congenital ocular toxoplasmosis were examined histologically. Toxoplasma tissue cysts and a subacute/chronic meningo-encephalitis were present in the brains of all infected mice. The findings were very similar to those seen in human congenital toxoplasmosis. The murine model of congenital toxoplasmic encephalitis described in this paper will be valuable in the study of the pathogenesis, natural history and treatment of this condition.
Original languageEnglish
Pages (from-to)265-277
Number of pages12
JournalJournal of Pathology
Volume142
Issue number4
DOIs
Publication statusPublished - 1984

Keywords

  • toxoplasmosis
  • congenital infection
  • encephalitis
  • ocular disease
  • mice

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