Enantiopure isoindolinones through Viedma ripening

René R. E. Steendam, Maxime C. T. Brouwer, Evelien M. E. Huijs, Michaël W. Kulka, Hugo Meekes, Willem J. P. van Enckevort, Jan Raap, Floris P. J. T. Rutjes, Elias Vlieg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.

Original languageEnglish
Pages (from-to)13527-13530
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number42
DOIs
Publication statusPublished - 13 Oct 2014

Keywords

  • crystallization
  • isoindoles
  • solubility
  • stereoisomerism
  • asymmetric amplification
  • chiral resolution
  • chirality
  • grinding
  • heterocycles

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  • Cite this

    Steendam, R. R. E., Brouwer, M. C. T., Huijs, E. M. E., Kulka, M. W., Meekes, H., van Enckevort, W. J. P., ... Vlieg, E. (2014). Enantiopure isoindolinones through Viedma ripening. Chemistry - A European Journal, 20(42), 13527-13530. https://doi.org/10.1002/chem.201404320