Abstract
Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.
Original language | English |
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Pages (from-to) | 13527-13530 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 42 |
DOIs | |
Publication status | Published - 13 Oct 2014 |
Keywords
- crystallization
- isoindoles
- solubility
- stereoisomerism
- asymmetric amplification
- chiral resolution
- chirality
- grinding
- heterocycles