Enabling model-predictive design: rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries

E. Ojo, H. Siddique, I. Houson, C. Brown, R. O'Meahdra, S. Berthold, A. Florence

Research output: Contribution to conferencePosterpeer-review

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Abstract

The study aimed to develop a rapid model using gProms Formulated Products for a proprietary single polymorph active pharmaceutical ingredient (API) crystallisation at small scale for early process understanding. The model outcomes are then later used to inform the experimental design of continuous crystallisation for multi-addition antisolvent and cooling crystallization in both continuous oscillatory
baffled reactor (COBC) and mixed-suspension and mixed- product removal (MSMPR) crystalliser
Original languageEnglish
Number of pages1
Publication statusPublished - 3 Nov 2019
EventAmerican Association of Pharmaceutical Scientists PharmSci 360, 2019 - San Antonio, United States
Duration: 3 Nov 20197 Nov 2019

Conference

ConferenceAmerican Association of Pharmaceutical Scientists PharmSci 360, 2019
Abbreviated titleAAPS PharmSci 360, 2019
Country/TerritoryUnited States
CitySan Antonio
Period3/11/197/11/19

Keywords

  • crystallisation
  • reactor geometries
  • continuous crystallisation

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