Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease

A Venneri, WJ McGeown, MF Shanks

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Abstract

Brain grey matter density changes were quantified using voxel based morphometry in 26 patients with minimal to mild Alzheimer's disease (AD) treated with three cholinesterase inhibitors over 20 weeks. Patients whose drug treatment also inhibited butyrylcholinesterase did not show the widespread cortical atrophic changes in parietotemporal regions invariably reported in untreated AD patients, and which were detectable in the subgroups treated with selective acetylcholinesterase inhibition. This finding is the first empirical evidence that dual cholinesterase inhibition may have neuroprotective potential in AD. (C) 2005 Lippincott Williams Wilkins.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalNeuroReport
Volume16
Issue number2
Publication statusPublished - 8 Feb 2005

Keywords

  • treatment
  • Alzheimer's disease
  • dementia
  • cholinesterase inhibitors
  • disease progression
  • donepezil
  • neuroimaging
  • grey matter
  • rivastigmine
  • galantamine
  • MRI

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