Emerging use of isotope ratio mass spectrometry as a tool for discrimination of 3,4-methylenedioxymethamphetamine by synthetic route

Hilary A.S. Buchanan, N.N. Daeid, Wolfram Meier-Augenstein, Helen F. Kemp, W.J. Kerr, Michael Middleditch

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Drug profiling, or the ability to link batches of illicit drugs to a common source or synthetic route, has long been a goal of law enforcement agencies. Research in the past decade has explored drug profiling with isotope ratio mass spectrometry (IRMS). This type of research can be limited by the use of substances seized by police, of which the provenance is unknown. Fortunately, however, some studies in recent years have been carried out on drugs synthesized in-house and therefore of known history. In this study, 18 MDMA samples were synthesized in-house from aliquots of the same precursor by three common reductive amination routes and analyzed for C-13, N-15, and H-2 isotope abundance using IRMS. For these three preparative methods, results indicate that H-2 isotope abundance data is necessary for discrimination by synthetic route. Furthermore, hierarchical cluster analysis using H-2 data on its own or combined with C-13 and/or N-15 provides a statistical means for accurate discrimination by synthetic route.
LanguageEnglish
Pages3350-3356
Number of pages6
JournalAnalytical Chemistry
Volume80
Issue number9
DOIs
Publication statusPublished - 1 May 2008

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Isotopes
Mass spectrometry
Law enforcement
Pharmaceutical Preparations
Amination
Cluster analysis
Street Drugs
History

Keywords

  • MDMA tablets
  • samples
  • ecstasy
  • heroin
  • origin
  • C-13
  • impurities
  • analogs
  • 3
  • 4-Methylenedioxyamphetamine
  • methamphetamine

Cite this

Buchanan, Hilary A.S. ; Daeid, N.N. ; Meier-Augenstein, Wolfram ; Kemp, Helen F. ; Kerr, W.J. ; Middleditch, Michael. / Emerging use of isotope ratio mass spectrometry as a tool for discrimination of 3,4-methylenedioxymethamphetamine by synthetic route. In: Analytical Chemistry. 2008 ; Vol. 80, No. 9. pp. 3350-3356.
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Emerging use of isotope ratio mass spectrometry as a tool for discrimination of 3,4-methylenedioxymethamphetamine by synthetic route. / Buchanan, Hilary A.S.; Daeid, N.N.; Meier-Augenstein, Wolfram; Kemp, Helen F.; Kerr, W.J.; Middleditch, Michael.

In: Analytical Chemistry, Vol. 80, No. 9, 01.05.2008, p. 3350-3356.

Research output: Contribution to journalArticle

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