Emerging role of interleukin-33 in autoimmune diseases

Cheng Pei, Mark Barbour, Karen J Fairlie-Clarke, Debbie Allan, Rong Mu, Hui-Rong Jiang

Research output: Contribution to journalReview articlepeer-review

76 Citations (Scopus)


Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
Issue number1
Publication statusPublished - Jan 2014


  • animals
  • atherosclerosis/immunology
  • autoimmune diseases/immunology
  • gene expression regulation/immunology
  • humans
  • interleukin-33
  • interleukins/immunology


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