Emerging role of interleukin-33 in autoimmune diseases

Cheng Pei, Mark Barbour, Karen J Fairlie-Clarke, Debbie Allan, Rong Mu, Hui-Rong Jiang

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

LanguageEnglish
Pages9-17
Number of pages9
JournalImmunology
Volume141
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Autoimmune Diseases
Nematode Infections
Interleukin-1
Atherosclerosis
Cytokines
Inflammation
Interleukin-33

Keywords

  • animals
  • atherosclerosis/immunology
  • autoimmune diseases/immunology
  • gene expression regulation/immunology
  • humans
  • interleukin-33
  • interleukins/immunology

Cite this

Pei, Cheng ; Barbour, Mark ; Fairlie-Clarke, Karen J ; Allan, Debbie ; Mu, Rong ; Jiang, Hui-Rong. / Emerging role of interleukin-33 in autoimmune diseases. In: Immunology. 2014 ; Vol. 141, No. 1. pp. 9-17.
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Pei, C, Barbour, M, Fairlie-Clarke, KJ, Allan, D, Mu, R & Jiang, H-R 2014, 'Emerging role of interleukin-33 in autoimmune diseases' Immunology, vol. 141, no. 1, pp. 9-17. https://doi.org/10.1111/imm.12174

Emerging role of interleukin-33 in autoimmune diseases. / Pei, Cheng; Barbour, Mark; Fairlie-Clarke, Karen J; Allan, Debbie; Mu, Rong; Jiang, Hui-Rong.

In: Immunology, Vol. 141, No. 1, 01.2014, p. 9-17.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Emerging role of interleukin-33 in autoimmune diseases

AU - Pei, Cheng

AU - Barbour, Mark

AU - Fairlie-Clarke, Karen J

AU - Allan, Debbie

AU - Mu, Rong

AU - Jiang, Hui-Rong

N1 - © 2013 John Wiley & Sons Ltd.

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AB - Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

KW - animals

KW - atherosclerosis/immunology

KW - autoimmune diseases/immunology

KW - gene expression regulation/immunology

KW - humans

KW - interleukin-33

KW - interleukins/immunology

U2 - 10.1111/imm.12174

DO - 10.1111/imm.12174

M3 - Review article

VL - 141

SP - 9

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SN - 0019-2805

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