Emerging iridium complexes for further applications in hydrogen isotope exchange

Research output: Contribution to conferencePoster

Abstract

Isotopic labelling with heavy hydrogen isotopes (D2 and T2 ) is widely used as a means to monitor the biological fate of a potential drug molecule.1 To circumvent additional synthetic steps in the drug design process, more direct, flexible, and selective means of introducing hydrogen isotopes continues to be the focus of considerable research attention. In relation to this, preliminary studies from our laboratory have allowed expedient access to a series of novel iridium complexes, many of which were previously inaccessible. By careful manipulation of the ligands supporting the iridium centre, these new catalysts can be applied under extremely mild reaction conditions and have now emerged to become some of the most active and, indeed, selective species known in this area of labelling chemistry.2 In a further extension to this overall programme of work, we are now using experimental and computational methods in parallel to optimise the design of our most successful catalysts. As a first step, investigations into the effect of changing the anionic portion of these complexes have been initiated to deliver complexes such as 2 (Scheme 1). This seemingly subtle adjustment of altering the catalyst counterion is now delivering unprecedented catalyst efficiency and, crucially, longevity. All studies to date will be delineated within this poster presentation.

Conference

ConferenceSuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates
CountryUnited Kingdom
CitySt Andrews
Period24/03/1326/03/13

Fingerprint

Iridium
Isotopes
Hydrogen
Catalysts
Labeling
Computational methods
Pharmaceutical Preparations
Ligands

Keywords

  • iridium complexes
  • hydrogen isotope exchange

Cite this

Kerr, W., & Reid, M. (2013). Emerging iridium complexes for further applications in hydrogen isotope exchange. Poster session presented at SuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates, St Andrews, United Kingdom.
Kerr, William ; Reid, Marc. / Emerging iridium complexes for further applications in hydrogen isotope exchange. Poster session presented at SuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates, St Andrews, United Kingdom.
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title = "Emerging iridium complexes for further applications in hydrogen isotope exchange",
abstract = "Isotopic labelling with heavy hydrogen isotopes (D2 and T2 ) is widely used as a means to monitor the biological fate of a potential drug molecule.1 To circumvent additional synthetic steps in the drug design process, more direct, flexible, and selective means of introducing hydrogen isotopes continues to be the focus of considerable research attention. In relation to this, preliminary studies from our laboratory have allowed expedient access to a series of novel iridium complexes, many of which were previously inaccessible. By careful manipulation of the ligands supporting the iridium centre, these new catalysts can be applied under extremely mild reaction conditions and have now emerged to become some of the most active and, indeed, selective species known in this area of labelling chemistry.2 In a further extension to this overall programme of work, we are now using experimental and computational methods in parallel to optimise the design of our most successful catalysts. As a first step, investigations into the effect of changing the anionic portion of these complexes have been initiated to deliver complexes such as 2 (Scheme 1). This seemingly subtle adjustment of altering the catalyst counterion is now delivering unprecedented catalyst efficiency and, crucially, longevity. All studies to date will be delineated within this poster presentation.",
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author = "William Kerr and Marc Reid",
year = "2013",
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Kerr, W & Reid, M 2013, 'Emerging iridium complexes for further applications in hydrogen isotope exchange' SuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates, St Andrews, United Kingdom, 24/03/13 - 26/03/13, .

Emerging iridium complexes for further applications in hydrogen isotope exchange. / Kerr, William; Reid, Marc.

2013. Poster session presented at SuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates, St Andrews, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Emerging iridium complexes for further applications in hydrogen isotope exchange

AU - Kerr, William

AU - Reid, Marc

PY - 2013/3/24

Y1 - 2013/3/24

N2 - Isotopic labelling with heavy hydrogen isotopes (D2 and T2 ) is widely used as a means to monitor the biological fate of a potential drug molecule.1 To circumvent additional synthetic steps in the drug design process, more direct, flexible, and selective means of introducing hydrogen isotopes continues to be the focus of considerable research attention. In relation to this, preliminary studies from our laboratory have allowed expedient access to a series of novel iridium complexes, many of which were previously inaccessible. By careful manipulation of the ligands supporting the iridium centre, these new catalysts can be applied under extremely mild reaction conditions and have now emerged to become some of the most active and, indeed, selective species known in this area of labelling chemistry.2 In a further extension to this overall programme of work, we are now using experimental and computational methods in parallel to optimise the design of our most successful catalysts. As a first step, investigations into the effect of changing the anionic portion of these complexes have been initiated to deliver complexes such as 2 (Scheme 1). This seemingly subtle adjustment of altering the catalyst counterion is now delivering unprecedented catalyst efficiency and, crucially, longevity. All studies to date will be delineated within this poster presentation.

AB - Isotopic labelling with heavy hydrogen isotopes (D2 and T2 ) is widely used as a means to monitor the biological fate of a potential drug molecule.1 To circumvent additional synthetic steps in the drug design process, more direct, flexible, and selective means of introducing hydrogen isotopes continues to be the focus of considerable research attention. In relation to this, preliminary studies from our laboratory have allowed expedient access to a series of novel iridium complexes, many of which were previously inaccessible. By careful manipulation of the ligands supporting the iridium centre, these new catalysts can be applied under extremely mild reaction conditions and have now emerged to become some of the most active and, indeed, selective species known in this area of labelling chemistry.2 In a further extension to this overall programme of work, we are now using experimental and computational methods in parallel to optimise the design of our most successful catalysts. As a first step, investigations into the effect of changing the anionic portion of these complexes have been initiated to deliver complexes such as 2 (Scheme 1). This seemingly subtle adjustment of altering the catalyst counterion is now delivering unprecedented catalyst efficiency and, crucially, longevity. All studies to date will be delineated within this poster presentation.

KW - iridium complexes

KW - hydrogen isotope exchange

UR - http://www.rsc.org/events/detail/8845/subicat-i-sustainable-catalytic-conversions-of-renewable-substrates

UR - http://subicat.org/images/swf/program.pdf

M3 - Poster

ER -

Kerr W, Reid M. Emerging iridium complexes for further applications in hydrogen isotope exchange. 2013. Poster session presented at SuBiCat I: Sustainable Catalytic Conversions of Renewable Substrates, St Andrews, United Kingdom.