Projects per year
Abstract
The phenomenon of fluorescence is the re-emission of light following absorption. It has led to a wide range of analytical techniques, particularly across molecular science and technology. Fluorescence has a multidimensional fingerprint that can include intensity, wavelength, excited state lifetime, polarization and position. To date little of this contour has been rapidly accessible in a single measurement, but the application of SPAD arrays is starting to address this limitation.
We have adapted the video rate capability of a prototype HORIBA FLIMera camera based on the Quanticam 192 x 128 pixel array1 to the development of two emerging applications of fluorescence lifetime imaging microscopy (FLIM) that are of key relevance to cancer diagnostics and treatment. These are the detection of low levels of circulating tumour cells using liquid biopsy for cancer screening2 and intraoperative fluorescence guided surgery3 for improved surgical precision.
We have adapted the video rate capability of a prototype HORIBA FLIMera camera based on the Quanticam 192 x 128 pixel array1 to the development of two emerging applications of fluorescence lifetime imaging microscopy (FLIM) that are of key relevance to cancer diagnostics and treatment. These are the detection of low levels of circulating tumour cells using liquid biopsy for cancer screening2 and intraoperative fluorescence guided surgery3 for improved surgical precision.
| Original language | English |
|---|---|
| Publication status | Published - 15 Jun 2022 |
| Event | International SPAD Sensor Workshop 2022 - On-line Duration: 13 Jun 2022 → 15 Jun 2022 https://issw2022.at/ |
Conference
| Conference | International SPAD Sensor Workshop 2022 |
|---|---|
| Period | 13/06/22 → 15/06/22 |
| Internet address |
Keywords
- fluorescence
- cancer screening
- SPADs
Other files and links
Fingerprint
Dive into the research topics of 'Emerging clinical applications of fluorescence using SPADs'. Together they form a unique fingerprint.Projects
- 3 Finished
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UK Quantum Technology Hub in Quantum Enhanced Imaging (Quantic) / R140296-202
Birch, D. (Principal Investigator), Chen, Y. (Co-investigator) & Li, D. (Co-investigator)
1/10/14 → 30/09/19
Project: Research - Internally Allocated
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UK Quantum Technology Hub in Quantum Enhanced Imaging (Quantic) / R140296-106
Birch, D. (Principal Investigator), Chen, Y. (Co-investigator) & Li, D. (Co-investigator)
1/10/14 → 30/09/19
Project: Research - Internally Allocated
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A new approach for imaging RNA at the single cell level
Chen, Y. (Principal Investigator), Birch, D. (Co-investigator) & Yu, J. (Co-investigator)
BBSRC (Biotech & Biological Sciences Research Council)
29/07/13 → 28/01/15
Project: Research
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Time will tell in fluorescence guided surgery
Birch, D. & Stewart, H. L., 9 Sept 2024.Research output: Contribution to conference › Keynote › peer-review
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Fluorescence guided surgery
Stewart, H. L. & Birch, D. J. S., 26 Aug 2021, In: Methods and Applications in Fluorescence . 9, 4, 26 p., 042002.Research output: Contribution to journal › Review article › peer-review
Open AccessFile52 Citations (Scopus)23 Downloads (Pure) -
Characterization of single channel liquid light guide coupling and SPAD array imaging for tumour margin estimation using fluorescence lifetime
Stewart, H. L., Hungerford, G. & Birch, D. J. S., 30 Sept 2020, In: Measurement Science and Technology . 31, 12, 12 p., 125701.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)80 Downloads (Pure)
Prizes
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Dennis Gabor Medal and Prize
Birch, D. (Recipient), 29 Oct 2020
Prize: Prize (including medals and awards)
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Director of Science and Technology HORIBA Jobin Yvon IBH Ltd
Birch, D. (Recipient), 2010
Prize: Appointment