Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2

Osama Idris Gibreel Khreit; Mary Grant; Tong Zhang; Catherine Henderson; David Watson; Oliver Brook Sutcliffe

doi:10.1016/j.jpba.2012.08.015

Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2

Osama Idris Gibreel Khreit, Mary Grant, Tong Zhang, Catherine Henderson, David Watson, Oliver Brook Sutcliffe

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Describes the elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2

Original language	English
Pages (from-to)	177-185
Number of pages	9
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	72
Early online date	29 Aug 2012
DOIs	https://doi.org/10.1016/j.jpba.2012.08.015
Publication status	Published - 2013

Keywords

nethylmethcathinone
rat liver hepatocytes
metabolic pathways
elucidation

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10.1016/j.jpba.2012.08.015

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Khreit, O. I. G., Grant, M., Zhang, T., Henderson, C., Watson, D., & Sutcliffe, O. B. (2013). Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2. Journal of Pharmaceutical and Biomedical Analysis, 72, 177-185. https://doi.org/10.1016/j.jpba.2012.08.015

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title = "Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2",

abstract = "Describes the elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2",

keywords = "nethylmethcathinone , rat liver hepatocytes , metabolic pathways , elucidation",

author = "Khreit, {Osama Idris Gibreel} and Mary Grant and Tong Zhang and Catherine Henderson and David Watson and Sutcliffe, {Oliver Brook}",

year = "2013",

doi = "10.1016/j.jpba.2012.08.015",

language = "English",

volume = "72",

pages = "177--185",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

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Khreit, OIG, Grant, M, Zhang, T, Henderson, C, Watson, D & Sutcliffe, OB 2013, 'Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2', Journal of Pharmaceutical and Biomedical Analysis, vol. 72, pp. 177-185. https://doi.org/10.1016/j.jpba.2012.08.015

Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2. / Khreit, Osama Idris Gibreel; Grant, Mary; Zhang, Tong et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 72, 2013, p. 177-185.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Khreit, Osama Idris Gibreel

AU - Grant, Mary

AU - Zhang, Tong

AU - Henderson, Catherine

AU - Watson, David

AU - Sutcliffe, Oliver Brook

PY - 2013

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AB - Describes the elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2

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KW - rat liver hepatocytes

KW - metabolic pathways

KW - elucidation

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Khreit OIG, Grant M, Zhang T, Henderson C, Watson D, Sutcliffe OB. Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2. Journal of Pharmaceutical and Biomedical Analysis. 2013;72:177-185. Epub 2012 Aug 29. doi: 10.1016/j.jpba.2012.08.015

Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2

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