Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia

Rodrigo Alberto Gonzalez-Montealegre; Alfredis González-Hernández; Jasmin Bonilla- Santos; Dorian Yisela Cala-Martínez; Mario Alfredo Parra

doi:10.1016/j.clinph.2025.01.009

Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia

Rodrigo Alberto Gonzalez-Montealegre, Alfredis González-Hernández^*, Jasmin Bonilla- Santos, Dorian Yisela Cala-Martínez, Mario Alfredo Parra^*

^*Corresponding author for this work

Psychology

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Abstract

Background

Visual Short-Term Memory Binding (VSTMB) is a preclinical marker of Alzheimer’s disease (AD). Reduced early event-related potentials (ERPs) (100–250 ms) over fronto-central (FC) and parieto-occipital (PO) regions have been reported in patients with Mild Cognitive Impairment (MCI) seen in the clinic. We investigated such ERPs in a larger sample of community-dwelling older adults who had not sought medical advice.

Methods

Participants (n = 215) were assessed with a neuropsychological battery and the VSTMB Task. The latter assessed the ability to detect changes between two consecutive arrays of shapes or colored shapes (the Binding condition). Time-locked EEG signals were collected during the task.

Results

Those who met the MCI criteria (n = 108) showed binding impairment. ERP analyses revealed significant Group x Time Windows interactions. Early ERP showed reduced neural recruitment (MCI < healthy controls (HC)) over the right FC regions, left PO, and right centro-parietal (CP) regions during Binding encoding, and over PO regions bilaterally and left FC during retrieval. Late ERP showed increased neural recruitment (MCI > HC) on left FC and PO regions during retrieval.

Conclusions

Hyper-recruitment may reflect functional reorganization aimed at behavioral compensation in the early stages of MCI. The role of such amplitude shifts as pointers of transition points in the AD continuum needs further investigation.

Original language	English
Pages (from-to)	227-239
Number of pages	13
Journal	Clinical Neurophysiology
Volume	171
Early online date	24 Jan 2025
DOIs	https://doi.org/10.1016/j.clinph.2025.01.009
Publication status	Published - 1 Mar 2025

Funding

This work was supported by the Science, Technology, and Innovation Fund- Huila of the General System of Royalties through the Ministry of Science, Technology, and Innovation of Colombia [BPIN 2020000100011] executed by Universidad Surcolombiana and Universidad de la Amazonia; and the agreement between Universidad Surcolombiana and Universidad Cooperativa de Colombia. This work was supported by Latin American Brain Health Institute (BrainLat) # BL-SRGP2020-02 awarded to MAP in collaboration with AGH.

Keywords

EEG
visual short-term memory binding
mild cognitive impairment
dementia biomarkers
community dwellers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinph.2025.01.009Licence: CC BY 4.0

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Cite this

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title = "Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia",

abstract = "BackgroundVisual Short-Term Memory Binding (VSTMB) is a preclinical marker of Alzheimer{\textquoteright}s disease (AD). Reduced early event-related potentials (ERPs) (100–250 ms) over fronto-central (FC) and parieto-occipital (PO) regions have been reported in patients with Mild Cognitive Impairment (MCI) seen in the clinic. We investigated such ERPs in a larger sample of community-dwelling older adults who had not sought medical advice.MethodsParticipants (n = 215) were assessed with a neuropsychological battery and the VSTMB Task. The latter assessed the ability to detect changes between two consecutive arrays of shapes or colored shapes (the Binding condition). Time-locked EEG signals were collected during the task.ResultsThose who met the MCI criteria (n = 108) showed binding impairment. ERP analyses revealed significant Group x Time Windows interactions. Early ERP showed reduced neural recruitment (MCI < healthy controls (HC)) over the right FC regions, left PO, and right centro-parietal (CP) regions during Binding encoding, and over PO regions bilaterally and left FC during retrieval. Late ERP showed increased neural recruitment (MCI > HC) on left FC and PO regions during retrieval.ConclusionsHyper-recruitment may reflect functional reorganization aimed at behavioral compensation in the early stages of MCI. The role of such amplitude shifts as pointers of transition points in the AD continuum needs further investigation.",

keywords = "EEG, visual short-term memory binding, mild cognitive impairment, dementia biomarkers, community dwellers",

author = "Gonzalez-Montealegre, {Rodrigo Alberto} and Alfredis Gonz{\'a}lez-Hern{\'a}ndez and {Bonilla- Santos}, Jasmin and Cala-Mart{\'i}nez, {Dorian Yisela} and Parra, {Mario Alfredo}",

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doi = "10.1016/j.clinph.2025.01.009",

language = "English",

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journal = "Clinical Neurophysiology",

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T1 - Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia

AU - Gonzalez-Montealegre, Rodrigo Alberto

AU - González-Hernández, Alfredis

AU - Bonilla- Santos, Jasmin

AU - Cala-Martínez, Dorian Yisela

AU - Parra, Mario Alfredo

PY - 2025/3/1

Y1 - 2025/3/1

N2 - BackgroundVisual Short-Term Memory Binding (VSTMB) is a preclinical marker of Alzheimer’s disease (AD). Reduced early event-related potentials (ERPs) (100–250 ms) over fronto-central (FC) and parieto-occipital (PO) regions have been reported in patients with Mild Cognitive Impairment (MCI) seen in the clinic. We investigated such ERPs in a larger sample of community-dwelling older adults who had not sought medical advice.MethodsParticipants (n = 215) were assessed with a neuropsychological battery and the VSTMB Task. The latter assessed the ability to detect changes between two consecutive arrays of shapes or colored shapes (the Binding condition). Time-locked EEG signals were collected during the task.ResultsThose who met the MCI criteria (n = 108) showed binding impairment. ERP analyses revealed significant Group x Time Windows interactions. Early ERP showed reduced neural recruitment (MCI < healthy controls (HC)) over the right FC regions, left PO, and right centro-parietal (CP) regions during Binding encoding, and over PO regions bilaterally and left FC during retrieval. Late ERP showed increased neural recruitment (MCI > HC) on left FC and PO regions during retrieval.ConclusionsHyper-recruitment may reflect functional reorganization aimed at behavioral compensation in the early stages of MCI. The role of such amplitude shifts as pointers of transition points in the AD continuum needs further investigation.

AB - BackgroundVisual Short-Term Memory Binding (VSTMB) is a preclinical marker of Alzheimer’s disease (AD). Reduced early event-related potentials (ERPs) (100–250 ms) over fronto-central (FC) and parieto-occipital (PO) regions have been reported in patients with Mild Cognitive Impairment (MCI) seen in the clinic. We investigated such ERPs in a larger sample of community-dwelling older adults who had not sought medical advice.MethodsParticipants (n = 215) were assessed with a neuropsychological battery and the VSTMB Task. The latter assessed the ability to detect changes between two consecutive arrays of shapes or colored shapes (the Binding condition). Time-locked EEG signals were collected during the task.ResultsThose who met the MCI criteria (n = 108) showed binding impairment. ERP analyses revealed significant Group x Time Windows interactions. Early ERP showed reduced neural recruitment (MCI < healthy controls (HC)) over the right FC regions, left PO, and right centro-parietal (CP) regions during Binding encoding, and over PO regions bilaterally and left FC during retrieval. Late ERP showed increased neural recruitment (MCI > HC) on left FC and PO regions during retrieval.ConclusionsHyper-recruitment may reflect functional reorganization aimed at behavioral compensation in the early stages of MCI. The role of such amplitude shifts as pointers of transition points in the AD continuum needs further investigation.

KW - EEG

KW - visual short-term memory binding

KW - mild cognitive impairment

KW - dementia biomarkers

KW - community dwellers

U2 - 10.1016/j.clinph.2025.01.009

DO - 10.1016/j.clinph.2025.01.009

M3 - Article

SN - 1388-2457

VL - 171

SP - 227

EP - 239

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

ER -

Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia

Abstract

Funding

Keywords

UN SDGs

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