Electrochemiluminescent sensors as a screening strategy for psychoactive substances within biological matrices

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Abstract

With the rapid growth and appearance of novel psychoactive substances (NPS) onto the global drug market, the need for alternative screening methodologies for implementation within clinical environments is substantial. The immunoassay methods currently in use are inadequate for this new drug trend with the potential for misdiagnosis and subsequent administration of incorrect patient treatment increased. This contribution illustrates a strong proof-of-concept for the use of electrochemiluminescence (ECL) as a screening methodology for NPS within biological fluids, using the hallucinogen scopolamine as a model compound. A low cost, easy-to-use and portable sensor has been developed and successfully employed for the detection of scopolamine at clinically relevant concentrations within a variety of biological matrices, including human pooled serum, urine, artificial saliva and sweat, without any prior sample preparation required. Moreover, assessment of the sensor's potential as a point-of-care wearable device was performed with sample collection from the surface of skin, demonstrating its capability for the qualitative identification of scopolamine despite collection of only minimal volumes off the skins surface. The developed sensor described herein exhibits a strong proof-of-concept for the employment of such ECL sensors as point-of-care devices, where the sensors ease of use and removal of time-consuming and complex sample preparation methods will ultimately increase its usability by physicians, widening the avenues where ECL sensors could be employed.

Original languageEnglish
Pages (from-to)4295-4304
Number of pages10
JournalAnalyst
Volume145
Issue number12
Early online date2 Jun 2020
DOIs
Publication statusPublished - 21 Jun 2020

Keywords

  • electrochemiluminescence (ECL)
  • sensor
  • psychoactive substance
  • forensic detection

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    Potentiostate CH760D

    Lynn Dennany (Manager)

    Pure And Applied Chemistry

    Facility/equipment: Equipment

  • Activities

    • 2 Invited talk
    • 1 Oral presentation

    Electrochemical approaches for rapid crime scene scree

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    24 Sep 201926 Sep 2019

    Activity: Talk or presentation typesInvited talk

    Mixed Luminophore ECL for the Differentiation Between Analytes of Similar Chemical Structure

    Lynn Dennany (Speaker), Kelly Brown (Speaker) & Pamela Allan (Contributor)

    22 Aug 201925 Aug 2019

    Activity: Talk or presentation typesOral presentation

    Illuminating Chemical Detection

    Lynn Dennany (Invited speaker)

    22 Aug 201925 Dec 2019

    Activity: Talk or presentation typesInvited talk

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